Induction of liver fibrosis in a murine hepatoma model by thioacetamide is associated with enhanced tumor growth and suppressed antitumor immunity

Ming Chen Yang, Chih Peng Chang, Huan Yao Lei

研究成果: Article同行評審

26 引文 斯高帕斯(Scopus)

摘要

Liver cirrhosis and hepatocellular carcinomas are two major causes of morbidity and mortality worldwide, and can synergistically interact to expedite the tumor progression. How fibrosis promotes the hepatoma growth remains completely unexplained. Using an in situ murine hepatoma model together with fibrosis induction by thioacetamide (TAA), the hepatoma growth and the immune factors in the fibrotic liver were analyzed. We found that TAA-fibrosis induction enhanced hepatoma cell growth in the liver and increased the mortality of hepatoma-bearing mice. The tumor-infiltrating CD4 or CD8 T cells are downregulated by fibrosis induction. The Foxp3 regulatory T cells (Treg) cells were induced. We conclude that fibrosis induction causes further immunosuppression, in which Treg cells exert a downregulation effect on the antitumor immunity.

原文English
頁(從 - 到)1782-1793
頁數12
期刊Laboratory Investigation
90
發行號12
DOIs
出版狀態Published - 2010 12月

All Science Journal Classification (ASJC) codes

  • 病理學與法醫學
  • 分子生物學
  • 細胞生物學

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