Inference of transcriptional regulatory network by bootstrapping patterns

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

Motivation: Transcriptional regulatory networks, which consist of linkages between transcription factors (TF) and target genes (TGene), control the expression of a genome and play important roles in all aspects of an organism's life cycle. Accurate prediction of transcriptional regulatory networks is critical in providing useful information for biologists to determine what to do next. Currently, there is a substantial amount of fragmented gene regulation information described in the medical literature. However, current related text analysis methods designed to identify protein-protein interactions are not entirely suitable for finding transcriptional regulatory networks.Result: In this article, we propose an automatic regulatory network inference method that uses bootstrapping of description patterns to predict the relationship between a TF and its TGenes. The proposed method differs from other regulatory network generators in that it makes use of both positive and negative patterns for different vector combinations in a sentence. Moreover, the positive pattern learning process can be fully automatic. Furthermore, patterns for active and passive voice sentences are learned separately. The experiments use 609 HIF-1 expert-tagged articles from PubMed as the gold standard. The results show that the proposed method can automatically generate a predicted regulatory network for a transcription factor. Our system achieves an F-measure of 72.60%.

原文English
文章編號btr155
頁(從 - 到)1422-1428
頁數7
期刊Bioinformatics
27
發行號10
DOIs
出版狀態Published - 2011 5月

All Science Journal Classification (ASJC) codes

  • 統計與概率
  • 生物化學
  • 分子生物學
  • 電腦科學應用
  • 計算機理論與數學
  • 計算數學

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