TY - JOUR
T1 - Inflammation in Wound Healing and Pathological Scarring
AU - Hong, Yi Kai
AU - Chang, Yi Han
AU - Lin, Yu Chen
AU - Chen, Brandon
AU - Guevara, Bryan Edgar K.
AU - Hsu, Chao Kai
N1 - Funding Information:
This work was supported by a grant from the Ministry of Science and Technology, Executive Yuan, Taiwan. (MOST 109-2326-B-006-004-MY3 to Chao-Kai Hsu). The authors thank Chien-Kuo Wang and Tzu-Ying Lu for the services of drawing figures in the Department of Audiovisuals, National Cheng Kung University Hospital, Learning Resource Center, College of Medicine, National Cheng Kung University.
Funding Information:
This work was supported by a grant from the Ministry of Science and Technology, Executive Yuan, Taiwan. (MOST 109-2326-B-006-004-MY3 to Chao-Kai Hsu). The authors thank Chien-Kuo Wang and Tzu-Ying Lu for the services of drawing figures in the Department of Audiovisuals, National Cheng Kung University Hospital, Learning Resource Center, College of Medicine, National Cheng Kung University.
Publisher Copyright:
© 2023 by Mary Ann Liebert, Inc., publishers.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Significance: The aberrant inflammation during wound healing results in pathological scarring, such as hypertrophic scars and keloids. This adversely affects the quality of life of patients due to the disfiguring appearance as well as the symptoms of itch and pain. This review summarizes the up-to-date knowledge of the immunopathogenesis and treatment options for pathological scars. Recent Advances: With the advent of new technologies, combined with in vitro and in vivo wound models, several inflammatory cells have been shown to have both direct and indirect effects on both wound healing and pathological scarring. Critical Issues: Expansion of pro-fibrotic immune cells such as M2 macrophages, dendritic cells, mast cells, and Th2 cells leads to fibroblast transition to myofibroblasts via transforming growth factor-β1 signaling pathway. Appropriate management of such inflammatory responses during wound healing remains a critical issue during clinical practice. Future Directions: Regulating inflammation response during wound healing may be a potential therapeutic option for avoiding or reducing pathological scars.
AB - Significance: The aberrant inflammation during wound healing results in pathological scarring, such as hypertrophic scars and keloids. This adversely affects the quality of life of patients due to the disfiguring appearance as well as the symptoms of itch and pain. This review summarizes the up-to-date knowledge of the immunopathogenesis and treatment options for pathological scars. Recent Advances: With the advent of new technologies, combined with in vitro and in vivo wound models, several inflammatory cells have been shown to have both direct and indirect effects on both wound healing and pathological scarring. Critical Issues: Expansion of pro-fibrotic immune cells such as M2 macrophages, dendritic cells, mast cells, and Th2 cells leads to fibroblast transition to myofibroblasts via transforming growth factor-β1 signaling pathway. Appropriate management of such inflammatory responses during wound healing remains a critical issue during clinical practice. Future Directions: Regulating inflammation response during wound healing may be a potential therapeutic option for avoiding or reducing pathological scars.
UR - http://www.scopus.com/inward/record.url?scp=85148678103&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85148678103&partnerID=8YFLogxK
U2 - 10.1089/wound.2021.0161
DO - 10.1089/wound.2021.0161
M3 - Article
C2 - 36541356
AN - SCOPUS:85148678103
SN - 2162-1918
VL - 12
SP - 288
EP - 300
JO - Advances in Wound Care
JF - Advances in Wound Care
IS - 5
ER -