Inflammation in Wound Healing and Pathological Scarring

Yi Kai Hong, Yi Han Chang, Yu Chen Lin, Brandon Chen, Bryan Edgar K. Guevara, Chao Kai Hsu

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)


Significance: The aberrant inflammation during wound healing results in pathological scarring, such as hypertrophic scars and keloids. This adversely affects the quality of life of patients due to the disfiguring appearance as well as the symptoms of itch and pain. This review summarizes the up-to-date knowledge of the immunopathogenesis and treatment options for pathological scars. Recent Advances: With the advent of new technologies, combined with in vitro and in vivo wound models, several inflammatory cells have been shown to have both direct and indirect effects on both wound healing and pathological scarring. Critical Issues: Expansion of pro-fibrotic immune cells such as M2 macrophages, dendritic cells, mast cells, and Th2 cells leads to fibroblast transition to myofibroblasts via transforming growth factor-β1 signaling pathway. Appropriate management of such inflammatory responses during wound healing remains a critical issue during clinical practice. Future Directions: Regulating inflammation response during wound healing may be a potential therapeutic option for avoiding or reducing pathological scars.

頁(從 - 到)288-300
期刊Advances in Wound Care
出版狀態Published - 2023 5月 1

All Science Journal Classification (ASJC) codes

  • 急診醫學
  • 重症監護和重症監護醫學


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