Influence of T cell specificity on the heterogeneity and disease-causing capability of antibody against the acetylcholine receptor

Trai-Ming Yeh, Keith A. Krolick

研究成果: Article同行評審

23 引文 斯高帕斯(Scopus)

摘要

Adoptive secondary anti-acetylcholine receptor (AChR) antibody responses were examined in rats to evaluate the influence of helper T cell specificity on the nature and disease-causing potential of antibody produced. Mixtures of B cells reactive with the intact AChR plus T cells reactive with purified AChR subunits (α, β, γ, δ) were transferred and antigen-challenged in immunologically naive recipient rats; the serum anti-AChR antibody produced was assessed by radioimmunoassay for differences in titers and by isoelectric focusing for differences in clonal heterogeneity as a function of the subunit specificity of T cells transferred. In addition, rats receiving different sources of AChR or AChR subunit-reactive T cells were examined for AChR-dependent muscle dysfunction. The results indicated a clear reduction in anti-AChR antibody concentrations and clonal heterogeneity in recipient rats receiving T cells of specificities restricted to individual subunits. However, except for a clear relationship between serum anti-AChR antibody concentration and disease induction, no particular AChR subunit-reactive helper T cell specificity appeared to preferentially cause muscle dysfunction. We conclude that if such relationships exists, T cells with specificities more restricted than those described here will have to be used.

原文English
頁(從 - 到)17-34
頁數18
期刊Journal of Neuroimmunology
17
發行號1
DOIs
出版狀態Published - 1987 一月 1

All Science Journal Classification (ASJC) codes

  • 免疫學和過敏
  • 免疫學
  • 神經內科
  • 神經病學(臨床)

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