Influence of thermal stress and various agents on the brain edema formation in rats following a cryogenic brain lesion

L. S. Lin, Wen-Tai Chiu, C. J. Shih, M. T. Lin

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

The influence of cold stress, heat stress, or various agents on the development of brain edema were assessed in rats following a cryogenic brain lesion. Brain edema was induced by local cold injury to the cortex. Cerebral edema was assessed 0.5, 3.0 or 24 h after a cryogenic brain lesion by measuring the water content of two hemispheres. Pretreatment of animals with sodium pentobarbital (15 or 30 mg/kg, i.p.) or lidocaine (15 mg/kg, i.p.) did not influence the development of brain edema. In addition, pretreatment with an external heat stress (heat exposure of 32°C for 6 h) exaggerated significantly the development of brain edema in the rat following a cryogenic brain lesion. On the other hand, pretreatment of animals with either external cold stress (cold exposure of 8°C for 6 h), glycerol (10% 10 ml, i.p.), mannitol (15% 10 ml, i.p.), gamma-hydroxybutyric acid(300 mg/kg, i.p.), metiamide (5 mg/kg, i.p.), dexamethasone (4 mg/kg, i.p.), aminophylline (100 mg/kg, i.p.), or ketamine (30 mg/kg, i.p.) inhibited significantly the brain edema formation.

原文English
頁(從 - 到)41-47
頁數7
期刊Chinese Journal of Physiology
32
發行號1
出版狀態Published - 1989 十二月 1

All Science Journal Classification (ASJC) codes

  • 生理學
  • 生理學(醫學)

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