Inhibition of group A streptococcus infection by carboxyfullerene

Nina Tsao, Tien Yau Luh, Chen Kung Chou, Jiunn Jong Wu, Yee Shin Lin, Huan Yao Lei

研究成果: Article同行評審

93 引文 斯高帕斯(Scopus)

摘要

The effect of a water-soluble trimalonic acid derivative of fullerene, carboxyfullerene, against Streptococcus pyogenes infection was tested. Pretreatment with carboxyfullerene was able to protect mice from S. pyogenes infection in an air pouch model. S. pyogenes-induced death and skin injury were inhibited dose dependently by carboxyfullerene. Administration of carboxyfullerene via the peritoneum and air pouch at 3 h post-S. pyogenes infection was able to protect 33% of mice from death. Surveys of exudates of the air pouch of carboxyfullerene-treated mice revealed that survival of infiltrating neutrophils was prolonged and that the bacteria were eliminated as a result of enhanced bactericidal activity of the neutrophils. Furthermore, carboxyfullerene was able to directly inhibit in vitro growth of S. pyogenes. These data suggest that carboxyfullerene can be considered an antimicrobial agent for group A streptococcus infection.

原文English
頁(從 - 到)1788-1793
頁數6
期刊Antimicrobial agents and chemotherapy
45
發行號6
DOIs
出版狀態Published - 2001 6月

All Science Journal Classification (ASJC) codes

  • 藥理
  • 藥學(醫學)
  • 傳染性疾病

指紋

深入研究「Inhibition of group A streptococcus infection by carboxyfullerene」主題。共同形成了獨特的指紋。

引用此