Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones

Su Jane Wang, Chiung Chun Huang, Kuei Sen Hsu, Jing Jane Tsai, Po Wu Gean

研究成果: Article同行評審

92 引文 斯高帕斯(Scopus)

摘要

LAMOTRIGINE (LAG) is a new anticonvulsant drug for the treatment of partial and secondarily generalized seizures. The present study was aimed at elucidating the possible involvement of Ca2+ channels in the action of LAG using whole-cell patch clamp recordings in acutely dissociated amygdalar neurones. Whole-cell Ca2+ currents (ICa) were elicited by 200 ms step commands from -70 mV to -10 mV. Application of LAG reduced the ICa by an average of 40.3 ± 3.2%. The inhibition of ICa by LAG was markedly reduced or eliminated in the presence of the N-type Ca2+ channel blocker ω-conotoxin-GVIA (1 μM). These results suggest that LAG may exert its anticonvulsant effect through inhibition of presynaptic N-type Ca2+ channels, thereby reducing glutamate release.

原文English
頁(從 - 到)3037-3040
頁數4
期刊NeuroReport
7
發行號18
DOIs
出版狀態Published - 1996

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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