Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

Chang Jer Wu; Jia Tsrong Jan; Chi Min Chen; Hsing Pang Hsieh; Der Ren Hwang; Hwan Wun Liu; Chiu Yi Liu; Hui Wen Huang; Su Chin Chen; Cheng Fong Hong; Ren Kuo Lin; Yu Sheng Chao; John T.A. Hsu

doi:10.1128/AAC.48.7.2693-2696.2004

Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

Chang Jer Wu, Jia Tsrong Jan, Chi Min Chen, Hsing Pang Hsieh, Der Ren Hwang, Hwan Wun Liu, Chiu Yi Liu, Hui Wen Huang, Su Chin Chen, Cheng Fong Hong, Ren Kuo Lin, Yu Sheng Chao, John T.A. Hsu

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180 引文斯高帕斯（Scopus）

摘要

Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

原文	English
頁（從 - 到）	2693-2696
頁數	4
期刊	Antimicrobial agents and chemotherapy
卷	48
發行號	7
DOIs	https://doi.org/10.1128/AAC.48.7.2693-2696.2004
出版狀態	Published - 2004 7月

All Science Journal Classification (ASJC) codes

藥理
藥學（醫學）
傳染性疾病

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10.1128/AAC.48.7.2693-2696.2004

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title = "Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide",

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AU - Wu, Chang Jer

AU - Jan, Jia Tsrong

AU - Chen, Chi Min

AU - Hsieh, Hsing Pang

AU - Hwang, Der Ren

AU - Liu, Hwan Wun

AU - Liu, Chiu Yi

AU - Huang, Hui Wen

AU - Chen, Su Chin

AU - Hong, Cheng Fong

AU - Lin, Ren Kuo

AU - Chao, Yu Sheng

AU - Hsu, John T.A.

PY - 2004/7

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N2 - Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

AB - Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

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JO - Antimicrobial Agents and Chemotherapy

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Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

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