Inhibition of Th2 cytokine production in T cells by monascin via PPAR-γ activation

Wei Hsuan Hsu, Bao Hong Lee, Ya Wen Hsu, Tzu Ming Pan

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)

摘要

Yellow pigment monascin (MS) is a secondary metabolite isolated from Monascus-fermented products and has numerous physiological activities. However, the potential use of MS for immunomodulation remains unclear. We showed that MS and the synthetic peroxisome proliferator-activated receptor (PPAR)-γ ligand rosiglitazone (RG) significantly inhibited the production of Th2 cytokines, including IL-4, IL-5, and IL-13, in PMA/ionomycin-activated mouse EL-4 T cells. Moreover, we showed that this was due to cellular PPAR-γ translocation. These results indicate that MS and RG promote PPAR-γ-DNA interactions and suggest that the regulatory effects of MS and RG on Th2 cytokine production could be abolished with PPAR-γ antagonist treatment. MS and RG also suppressed Th2 transcription factor translocation (e.g., GATA-3 and nuclear factor of activated T cells) by preventing the phosphorylation of protein kinase C and signal transducer and activator of transcription 6.

原文English
頁(從 - 到)8126-8133
頁數8
期刊Journal of Agricultural and Food Chemistry
61
發行號34
DOIs
出版狀態Published - 2013 8月 28

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 農業與生物科學 (全部)

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