Inhibition of the increased permeability of blood-brain barrier in escherichia coli-induced meningitis by carboxyfullerene

Nina Tsao, Ching Ming Wu, Hui Ping Hsu, Ching Chuan Liu, Tien Yau Luh, Chen Kung Chou, Huan Yao Lei

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)

摘要

The effect of a water-soluble trimalonic acid derivative of fullerene, carboxyfullerene (C63(COOH)6), on the opening of blood-brain barrier (BBB) in Escherichia coli (E. coli)-induced meningitis was tested. In E. coli-induced meningitis model, the increase of BBB permeability was manifested in two distinct phases based on cytokine expression pattern and neutrophilic infiltration in B6 mice. An early increase in BBB permeability was occurred at 1-5 h post injection that could be blocked by either anti-TNF-α or anti-IL-1β antibodies. A late one (neutrophil-associated BBB opening) was manifested at 6-12 h that was inhibited by vinblastine pretreatment. Inhibition of the early E. coli-induced BBB opening blocked the development of the late one. Furthermore, the neutrophil-associated BBB opening (the late phase), but not cytokine-induced one (the early phase), was inhibited by a water-soluble carboxyfullerene.

原文English
頁(從 - 到)307-320
頁數14
期刊Fullerene Science and Technology
9
發行號3
DOIs
出版狀態Published - 2001 8月

All Science Journal Classification (ASJC) codes

  • 一般化學工程

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