Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging

Chien Liang Liu; Hung Tsung Wu; Yi Hsuan Hsiao; Chih Wei Lai; Chun Wei Shih; Yung Kang Peng; Kuo Chun Tang; Hsing Wei Chang; Yun Chen Chien; Jong Kai Hsiao; Juei Tang Cheng; Pi Tai Chou

doi:10.1002/anie.201100299

Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging

Chien Liang Liu, Hung Tsung Wu, Yi Hsuan Hsiao, Chih Wei Lai, Chun Wei Shih, Yung Kang Peng, Kuo Chun Tang, Hsing Wei Chang, Yun Chen Chien, Jong Kai Hsiao, Juei Tang Cheng, Pi Tai Chou

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研究成果: Article › 同行評審

371 引文斯高帕斯（Scopus）

摘要

Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

原文	English
頁（從 - 到）	7056-7060
頁數	5
期刊	Angewandte Chemie - International Edition
卷	50
發行號	31
DOIs	https://doi.org/10.1002/anie.201100299
出版狀態	Published - 2011 7月 25

All Science Journal Classification (ASJC) codes

催化
化學 (全部)

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10.1002/anie.201100299

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Liu, C. L., Wu, H. T., Hsiao, Y. H., Lai, C. W., Shih, C. W., Peng, Y. K., Tang, K. C., Chang, H. W., Chien, Y. C., Hsiao, J. K., Cheng, J. T., & Chou, P. T. (2011). Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging. Angewandte Chemie - International Edition, 50(31), 7056-7060. https://doi.org/10.1002/anie.201100299

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abstract = "Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).",

author = "Liu, {Chien Liang} and Wu, {Hung Tsung} and Hsiao, {Yi Hsuan} and Lai, {Chih Wei} and Shih, {Chun Wei} and Peng, {Yung Kang} and Tang, {Kuo Chun} and Chang, {Hsing Wei} and Chien, {Yun Chen} and Hsiao, {Jong Kai} and Cheng, {Juei Tang} and Chou, {Pi Tai}",

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Liu, CL, Wu, HT, Hsiao, YH, Lai, CW, Shih, CW, Peng, YK, Tang, KC, Chang, HW, Chien, YC, Hsiao, JK, Cheng, JT & Chou, PT 2011, 'Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging', Angewandte Chemie - International Edition, 卷 50, 編號 31, 頁 7056-7060. https://doi.org/10.1002/anie.201100299

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T1 - Insulin-directed synthesis of fluorescent gold nanoclusters

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AU - Liu, Chien Liang

AU - Wu, Hung Tsung

AU - Hsiao, Yi Hsuan

AU - Lai, Chih Wei

AU - Shih, Chun Wei

AU - Peng, Yung Kang

AU - Tang, Kuo Chun

AU - Chang, Hsing Wei

AU - Chien, Yun Chen

AU - Hsiao, Jong Kai

AU - Cheng, Juei Tang

AU - Chou, Pi Tai

PY - 2011/7/25

Y1 - 2011/7/25

N2 - Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

AB - Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 31

ER -

Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging

摘要

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