Integrated microfluidic systems for screening of aptamers specific to cardiovascular biomarkers

Anirban Sinha, Yi Da Chung, Priya Gopinathan, Lien Yu Hung, Ching Hsuan Yang, Shu Chu Shiesh, Gwo Bin Lee

研究成果: Conference contribution

2 引文 斯高帕斯(Scopus)

摘要

Current biomedical sensing processes vastly rely on antigen-antibody based detection processes, which have limitations in point-of-care applications. Recently, an artificial antibody, aptamer, has emerging as a promising candidate for diagnosis, which could be screened from a process called systematic evolution of ligands by exponential enrichment (SELEX). In this study, we have developed a new, automated, miniaturized SELEX platform for screening of affinity reagents towards protein biomarkers for cardiovascular diseases (CVDs). As a demonstration, we reported for the first time a complete 'on-chip process to screen aptamers for targeting N-terminal pro b-type natriuretic peptide (NT-pro BNP)' on an integrated microfluidic system.

原文English
主出版物標題20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
發行者Chemical and Biological Microsystems Society
頁面67-68
頁數2
ISBN(電子)9780979806490
出版狀態Published - 2016
事件20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
持續時間: 2016 十月 92016 十月 13

出版系列

名字20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
國家Ireland
城市Dublin
期間16-10-0916-10-13

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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