Intelligent Wireless EEG Measurement System with Electrical and Optogenetic Stimulation for Epileptic Seizure Detection and Suppression

Wei En Lee; Chieh Tsou; Zhan Xian Liao; Po Yen Lu; Tsung Hsien Lin; Shuenn Yuh Lee; Chou Ching K. Lin; Gia Shing Shieh

doi:10.1109/ACCESS.2021.3083772

Intelligent Wireless EEG Measurement System with Electrical and Optogenetic Stimulation for Epileptic Seizure Detection and Suppression

Wei En Lee, Chieh Tsou, Zhan Xian Liao, Po Yen Lu, Tsung Hsien Lin, Shuenn Yuh Lee, Chou Ching K. Lin, Gia Shing Shieh

研究成果: Article › 同行評審

摘要

A two-channel real-time intelligent electroencephalography (EEG) measurement system with electrical and optical stimulations is presented for seizure detection and suppression. Based on software control through a wireless interface, this system provides closed-and open-loop feedback control with programmable waveform for electrical and optical stimulations. Matlab graphical user interface is used to monitor the intracranial EEG, perform the algorithm for seizure detection, and adjust the required intensity, frequency, duty cycle, and duration of electrical and optical stimulations. The whole hardware device is embedded on a printed circuit board with the size of 27.3 mm ×23.6 mm. C57BL/6 mice with Thy1-ChR2-YFP gene transfer and drug-induced seizure are used to demonstrate epileptic seizure suppression according to electrical and optogenetic stimulation in the proposed wireless EEG measurement system.

原文	English
文章編號	9440937
頁（從 - 到）	80264-80274
頁數	11
期刊	IEEE Access
卷	9
DOIs	https://doi.org/10.1109/ACCESS.2021.3083772
出版狀態	Published - 2021

All Science Journal Classification (ASJC) codes

電腦科學(全部)
材料科學(全部)
工程 (全部)

存取文件

10.1109/ACCESS.2021.3083772

其它文件與鏈接

引用此

@article{e801e5928f8947788020bd89541bd412,

title = "Intelligent Wireless EEG Measurement System with Electrical and Optogenetic Stimulation for Epileptic Seizure Detection and Suppression",

abstract = "A two-channel real-time intelligent electroencephalography (EEG) measurement system with electrical and optical stimulations is presented for seizure detection and suppression. Based on software control through a wireless interface, this system provides closed-and open-loop feedback control with programmable waveform for electrical and optical stimulations. Matlab graphical user interface is used to monitor the intracranial EEG, perform the algorithm for seizure detection, and adjust the required intensity, frequency, duty cycle, and duration of electrical and optical stimulations. The whole hardware device is embedded on a printed circuit board with the size of 27.3 mm ×23.6 mm. C57BL/6 mice with Thy1-ChR2-YFP gene transfer and drug-induced seizure are used to demonstrate epileptic seizure suppression according to electrical and optogenetic stimulation in the proposed wireless EEG measurement system.",

author = "Lee, {Wei En} and Chieh Tsou and Liao, {Zhan Xian} and Lu, {Po Yen} and Lin, {Tsung Hsien} and Lee, {Shuenn Yuh} and Lin, {Chou Ching K.} and Shieh, {Gia Shing}",

note = "Funding Information: This work involved human subjects or animals in its research. Approval of all ethical and experimental procedures and protocols was granted by the Institutional Animal Care and Use Committee (IACUC). Funding Information: This work was supported in part by the Taiwan Semiconductor Research Institute, and in part by the Ministry of Science and Technology (MOST), Taiwan, under Grant MOST 109-2221-E-002-138-MY2. Publisher Copyright: {\textcopyright} 2013 IEEE.",

year = "2021",

doi = "10.1109/ACCESS.2021.3083772",

language = "English",

volume = "9",

pages = "80264--80274",

journal = "IEEE Access",

issn = "2169-3536",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

TY - JOUR

T1 - Intelligent Wireless EEG Measurement System with Electrical and Optogenetic Stimulation for Epileptic Seizure Detection and Suppression

AU - Lee, Wei En

AU - Tsou, Chieh

AU - Liao, Zhan Xian

AU - Lu, Po Yen

AU - Lin, Tsung Hsien

AU - Lee, Shuenn Yuh

AU - Lin, Chou Ching K.

AU - Shieh, Gia Shing

N1 - Funding Information: This work involved human subjects or animals in its research. Approval of all ethical and experimental procedures and protocols was granted by the Institutional Animal Care and Use Committee (IACUC). Funding Information: This work was supported in part by the Taiwan Semiconductor Research Institute, and in part by the Ministry of Science and Technology (MOST), Taiwan, under Grant MOST 109-2221-E-002-138-MY2. Publisher Copyright: © 2013 IEEE.

PY - 2021

Y1 - 2021

N2 - A two-channel real-time intelligent electroencephalography (EEG) measurement system with electrical and optical stimulations is presented for seizure detection and suppression. Based on software control through a wireless interface, this system provides closed-and open-loop feedback control with programmable waveform for electrical and optical stimulations. Matlab graphical user interface is used to monitor the intracranial EEG, perform the algorithm for seizure detection, and adjust the required intensity, frequency, duty cycle, and duration of electrical and optical stimulations. The whole hardware device is embedded on a printed circuit board with the size of 27.3 mm ×23.6 mm. C57BL/6 mice with Thy1-ChR2-YFP gene transfer and drug-induced seizure are used to demonstrate epileptic seizure suppression according to electrical and optogenetic stimulation in the proposed wireless EEG measurement system.

AB - A two-channel real-time intelligent electroencephalography (EEG) measurement system with electrical and optical stimulations is presented for seizure detection and suppression. Based on software control through a wireless interface, this system provides closed-and open-loop feedback control with programmable waveform for electrical and optical stimulations. Matlab graphical user interface is used to monitor the intracranial EEG, perform the algorithm for seizure detection, and adjust the required intensity, frequency, duty cycle, and duration of electrical and optical stimulations. The whole hardware device is embedded on a printed circuit board with the size of 27.3 mm ×23.6 mm. C57BL/6 mice with Thy1-ChR2-YFP gene transfer and drug-induced seizure are used to demonstrate epileptic seizure suppression according to electrical and optogenetic stimulation in the proposed wireless EEG measurement system.

UR - http://www.scopus.com/inward/record.url?scp=85107174895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85107174895&partnerID=8YFLogxK

U2 - 10.1109/ACCESS.2021.3083772

DO - 10.1109/ACCESS.2021.3083772

M3 - Article

AN - SCOPUS:85107174895

SN - 2169-3536

VL - 9

SP - 80264

EP - 80274

JO - IEEE Access

JF - IEEE Access

M1 - 9440937

ER -

Intelligent Wireless EEG Measurement System with Electrical and Optogenetic Stimulation for Epileptic Seizure Detection and Suppression

摘要

All Science Journal Classification (ASJC) codes

存取文件

其它文件與鏈接

指紋

引用此