Interactive effects between CYP1A1 genotypes and environmental polychlorinated dibenzo-p-dioxins and dibenzofurans exposures on liver function profile

研究成果: Article

2 引文 (Scopus)

摘要

Previous studies reported that polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) induced hepatic cytochrome P-4501A1 (CYP1A1). The aim of this study was to examine the interactive influence of CYP1A1 genotypes and PCDD/Fs exposure on liver function profile. PCDD/Fs levels and liver function parameters were determined in serum and correlated with genetic polymorphism of CYP1A1/Msp 1 in 225 human volunteers who had no or minimal occupational exposure to PCDD/F. The results showed that the highest glutamate pyruvate transaminase (GPT) activity levels were found in subjects with homozygous variant CYP1A1/Msp 1, followed by heterozygous variant, and finally homozygous wild type for those individuals whose serum PCDD/Fs levels were higher than 17.4 pg WHO-TEQ/g lipid. Data suggest that GPT activity levels may be modified by interaction of CYP1A1/Msp 1 genotype with dioxin after adjustment for age, alcohol consumption, and history of liver illness. Further studies are needed to characterize the variation in other related genes to verify whether a correlation exists between serum PCDD/Fs levels and adverse health effects.

原文English
頁(從 - 到)269-281
頁數13
期刊Journal of Toxicology and Environmental Health - Part A
69
發行號4
DOIs
出版狀態Published - 2006 一月 1

指紋

Cytochromes
Liver
Genotype
Transaminases
Pyruvic Acid
Glutamic Acid
Serum
Dioxins
Polymorphism
Genetic Polymorphisms
Occupational Exposure
Alcohol Drinking
Genes
Health Status
Alcohols
Dibenzofurans
Polychlorinated Dibenzodioxins
dibenzo(1,4)dioxin
Health
Volunteers

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

引用此文

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title = "Interactive effects between CYP1A1 genotypes and environmental polychlorinated dibenzo-p-dioxins and dibenzofurans exposures on liver function profile",
abstract = "Previous studies reported that polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) induced hepatic cytochrome P-4501A1 (CYP1A1). The aim of this study was to examine the interactive influence of CYP1A1 genotypes and PCDD/Fs exposure on liver function profile. PCDD/Fs levels and liver function parameters were determined in serum and correlated with genetic polymorphism of CYP1A1/Msp 1 in 225 human volunteers who had no or minimal occupational exposure to PCDD/F. The results showed that the highest glutamate pyruvate transaminase (GPT) activity levels were found in subjects with homozygous variant CYP1A1/Msp 1, followed by heterozygous variant, and finally homozygous wild type for those individuals whose serum PCDD/Fs levels were higher than 17.4 pg WHO-TEQ/g lipid. Data suggest that GPT activity levels may be modified by interaction of CYP1A1/Msp 1 genotype with dioxin after adjustment for age, alcohol consumption, and history of liver illness. Further studies are needed to characterize the variation in other related genes to verify whether a correlation exists between serum PCDD/Fs levels and adverse health effects.",
author = "Hsiu-Ling Chen and Huey-Jen Su and Ying-Jan Wang and Guo, {Yue Liang} and Pao-Chi Liao and Ching-Chang Lee",
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AU - Guo, Yue Liang

AU - Liao, Pao-Chi

AU - Lee, Ching-Chang

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