Interampatteness - A generic property of biochemical networks

T. E.M. Nordling, E. W. Jacobsen

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Analysis of gene expression data sets reveals that the variation in expression is concentrated to significantly fewer 'characteristic modes' or 'eigengenes' than the number of both recorded assays and measured genes. Previous works have stressed the importance of these characteristic modes, but neglected the equally important weak modes. Herein a generic system property - interampatteness - is defined that explains the previous feature, and assigns equal weight to the characteristic and weak modes. An interampatte network is characterised by strong INTERactions enabling simultaneous AMPlification and ATTEnuation of different signals. It is postulated that biochemical networks are interampatte, based on published experimental data and theoretical considerations. Existence of multiple time-scales and feedback loops is shown to increase the degree of interampatteness. Interampatteness has strong implications for the dynamics and reverse engineering of the network. One consequence is highly correlated changes in gene expression in response to external perturbations, even in the absence of common transcription factors, implying that interampatte gene regulatory networks erroneously may be assumed to have co-expressed/ co-regulated genes. Data compression or reduction of the system dimensionality using clustering, singular value decomposition, principal component analysis or some other data mining technique results in a loss of information that will obstruct reconstruction of the underlying network.

原文English
頁(從 - 到)388-403
頁數16
期刊IET Systems Biology
3
發行號5
DOIs
出版狀態Published - 2009 十月 2

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Modelling and Simulation
  • Molecular Biology
  • Genetics
  • Cell Biology

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