Interferon Family Cytokines in Obesity and Insulin Sensitivity

Ling Yu Huang, Chiao Juno Chiu, Chung Hsi Hsing, Yu Hsiang Hsu

研究成果: Review article同行評審

4 引文 斯高帕斯(Scopus)


Obesity and its associated complications are global public health concerns. Metabolic disturbances and immune dysregulation cause adipose tissue stress and dysfunction in obese individuals. Immune cell accumulation in the adipose microenvironment is the main cause of insulin resistance and metabolic dysfunction. Infiltrated immune cells, adipocytes, and stromal cells are all involved in the production of proinflammatory cytokines and chemokines in adipose tissues and affect systemic homeostasis. Interferons (IFNs) are a large family of pleiotropic cytokines that play a pivotal role in host antiviral defenses. IFNs are critical immune modulators in response to pathogens, dead cells, and several inflammation-mediated diseases. Several studies have indicated that IFNs are involved in the pathogenesis of obesity. In this review, we discuss the roles of IFN family cytokines in the development of obesity-induced inflammation and insulin resistance.

出版狀態Published - 2022 12月

All Science Journal Classification (ASJC) codes

  • 生物化學、遺傳與分子生物學 (全部)


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