Interleukin-19 in breast cancer

Ying Yin Chen, Chien Feng Li, Ching Hua Yeh, Ming Shi Chang, Chung Hsi Hsing

研究成果: Review article同行評審

14 引文 斯高帕斯(Scopus)

摘要

Inflammatory cytokines within the tumor microenvironment are linked to progression in breast cancer. Interleukin- (IL-) 19, part of the IL-10 family, contributes to a range of diseases and disorders, such as asthma, endotoxic shock, uremia, psoriasis, and rheumatoid arthritis. IL-19 is expressed in several types of tumor cells, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung and invasive duct carcinoma of the breast. In breast cancer, IL-19 expression is correlated with increased mitotic figures, advanced tumor stage, higher metastasis, and poor survival. The mechanisms of IL-19 in breast cancer have recently been explored both in vitro and in vivo. IL-19 has an autocrine effect in breast cancer cells. It directly promotes proliferation and migration and indirectly provides a microenvironment for tumor progression, which suggests that IL-19 is a prognostic marker in breast cancer and that antagonizing IL-19 may have therapeutic potential.

原文English
文章編號294320
期刊Clinical and Developmental Immunology
2013
DOIs
出版狀態Published - 2013

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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