Interplay between miRNAs and host genes and their role in cancer

Baohong Liu, Yu Shyr, Jianping Cai, Qi Liu

研究成果: Article同行評審

33 引文 斯高帕斯(Scopus)

摘要

MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-transcriptionally regulate gene expression. They play essential roles in nearly all biological processes including cell development and differentiation, DNA damage repair, cell death as well as intercellular communication. They are highly involved in cancer, acting as tumor suppressors and/or promoters to modulate cell proliferation, epithelial-mesenchymal transition and tumor invasion and metastasis. Recent studies have shown that more than half of miRNAs are located within protein-coding or non-coding genes. Intragenic miRNAs and their host genes either share the promoter or have independent transcription. Meanwhile, miRNAs work as partners or antagonists of their host genes by fine-tuning their target genes functionally associated with host genes. This review outlined the complicated relationship between intragenic miRNAs and host genes. Focusing on miRNAs known as oncogenes or tumor suppressors in specific cancer types, it studied co-expression relationships between these miRNAs and host genes in the cancer types using TCGA data sets, which validated previous findings and revealed common, tumor-specific and even subtype-specific patterns. These observations will help understand the function of intragenic miRNAs and further develop miRNA therapeutics in cancer.

原文English
頁(從 - 到)255-266
頁數12
期刊Briefings in functional genomics
18
發行號4
DOIs
出版狀態Published - 2019 七月 22

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子生物學
  • 遺傳學

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