Intra-articular injection of (-)-epigallocatechin 3-gallate to attenuate articular cartilage degeneration by enhancing autophagy in a post-traumatic osteoarthritis rat model

Hsuan Ti Huang, Tsung Lin Cheng, Cheng Jung Ho, Han Hsiang Huang, Cheng Chang Lu, Shu Chun Chuang, Jhong You Li, Tien Ching Lee, Shih Tse Chen, Yi Shan Lin, Chih Yao Lee, Lin Kang, Sung Yen Lin, Chung Hwan Chen

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

(-)-Epigallocatechin 3-gallate (EGCG) is the main active green tea catechin and has a wide variety of benefits for health. Post-traumatic osteoarthritis (PTOA) occurs as a consequence of joint injuries that commonly happen in the young population. In this study, we investigated the effects of EGCG on PTOA prevention by using the anterior cruciate ligament transection (ACLT)–OA model and further investigated the roles of autophagy in OA treatment. Our results showed that intra-articular injection of EGCG significantly improved the functional performances and decreased cartilage degradation. EGCG treatment attenuated the inflammation on synovial tissue and cartilage through less immunostained cyclooxygenase-2 and matrix metalloproteinase-13. We further noted EGCG may modulate the chondrocyte apoptosis by activation of the cytoprotective autophagy through reducing the expression of the mTOR and enhancing the expression of microtubule-associated protein light chain 3, beclin-1, and p62. In conclusion, intra-articular injection of EGCG after ACL injury inhibited the joint inflammation and cartilage degradation, thereby increasing joint function. EGCG treatment also reduced the chondrocyte apoptosis, possibly by activating autophagy. These findings suggested that EGCG may be a potential disease-modifying drug for preventing OA progression.

原文English
文章編號8
頁(從 - 到)1-16
頁數16
期刊Antioxidants
10
發行號1
DOIs
出版狀態Published - 2021 一月

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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