Intraovarian Injection of Recombinant Human Follicle‐ Stimulating Hormone for Luteal‐Phase Ovarian Stimulation during Oocyte Retrieval Is Effective in Women with Impending Ovarian Failure and Diminished Ovarian Reserve

Chao Chin Hsu, Isabel Hsu, Li Hsuan Lee, Yuan-Shuo Hsueh, Chih Ying Lin, Hui Hua Chang

研究成果: Article同行評審

摘要

It is a challenge to obtain sufficient eggs during in vitro fertilization (IVF) in women with impending ovarian failure (IOF)/diminished ovarian reserve (DOR). Although studies have suggested that more than one wave of follicle growth exists, the efficacy of controlled ovulation stimulation (COS) in both follicular and luteal phases of the same ovarian cycle (DuoStim) is not established in women with IOF/DOR. We investigated the efficacy of DuoStim using the intraovarian injection of recombinant human follicle‐stimulating hormone (rhFSH) during oocyte retrieval in women with DOR. For luteal‐phase stimulation, intraovarian (Group A, N = 28) or superficial subcutaneous (Group B, N = 18) injection of 300 IU rhFSH immediately after oocyte retrieval was administered as the first dose, and intermittent superficial subcutaneous addition of gonadotropins was employed accordingly for further COS in both groups. In Group A, significantly lower Gn doses, a shorter duration of COS, a greater number of antral follicle counts, and an increased number of retrieved mature and total oocytes were noted. Compared with the clinical outcomes of lutealphase COS, the average daily doses of rhFSH used in Group A were significantly lower. In summary, the novel approach using intraovarian rhFSH injection provides an efficient treatment regimen in women with IOF/DOR.

原文English
文章編號1312
期刊Biomedicines
10
發行號6
DOIs
出版狀態Published - 2022 6月

All Science Journal Classification (ASJC) codes

  • 醫藥(雜項)
  • 生物化學、遺傳與分子生物學 (全部)

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