Intraperitoneal hyperthermia in the management of pseudomyxoma peritonei

Kai Hsi Hsu, Cheng Yang Chou, Yu Chung Chang

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)


Background/Aims: Pseudomyxoma peritonei is a rare disease characterized by diffuse intraperitoneal mucinous tumor and massive mucinous ascites. The mainstay of treatment is surgery in combination with adjuvant therapy. Methodology: From 1995 to 2002, 8 patients with pathologically confirmed pseudomyxoma peritonei were studied. After surgical debulking, intraoperative intraperitoneal hyperthermia was performed followed by 5 days of postoperative intraperitoneal hyperthermia. Normal saline at 46° C was used for hyperthermia. Patients were followed for clinical data, survival, morbidity, and mortality Results: The appendix was the origin of pseudomyxoma peritonei in 6 patients, the ovary in 1 patient, and the fallopian tube in another. The pathologic diagnosis was mucinous adenocarcinoma in 4 patients, mucinous cystadenocarcinoma in 3, and mucinous cystadenoma in 1. Associated morbidity and mortality was 12.5% and 0, respectively. The recurrence rate was 62.5%, with a median follow-up of 52.5 months. The estimated 1-, 3-, and 5-year survival rates were 100%, 88%, and 49%, respectively. Conclusions: Surgical debulking followed by 46 °C normal saline intraperitoneal hyperthermia resulted in a 5-year survival of 49% with low morbidity and no mortality for the treatment of pseudomyxoma peritonei. We concluded that this is an easy, safe, and efficacious treatment for patients with this rare disease.

頁(從 - 到)47-52
出版狀態Published - 2007 一月 1

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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