Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats

Ching-Hsia Hung, Jhi Joung Wang, Yu Chung Chen, Chin Chen Chu, Yu Wen Chen

研究成果: Article

27 引文 (Scopus)

摘要

Proxymetacaine and oxybuprocaine were clinically used for topical ocular anesthesia but never for spinal anesthesia, and therefore spinal anesthetic effects of proxymetacaine and oxybuprocaine were performed and compared with bupivacaine and lidocaine. After rats were injected intrathecally with proxymetacaine, oxybuprocaine, bupivacaine, and lidocane, dose-response curves were constructed. We evaluated the potencies (ED50) and durations (time to full recovery) of proxymetacaine and oxybuprocaine on spinal blockades of motor function, proprioception, and nociception and compared with bupivacaine and lidocaine in rats. We found that proxymetacaine and oxybuprocaine acted like bupivacaine or lidocaine and produced dose-related spinal blockades of motor function, proprioception and nociception. On the ED50 basis, the ranks of potencies in motor, proprioception, and nociception were proxymetacaine > oxybuprocaine > bupivacaine > lidocaine (P < 0.01 for the differences). On an equipotent basis (ED20, ED50, ED80), oxybuprocaine and bupivacaine produced similarly longer spinal blockades than did proxymetacaine or lidocaine (P < 0.05 for the differences). Intrathecal proxymetacaine, oxybuprocaine, and bupivacaine also produced longer sensory blockade than motor blockade. These data demonstrated that oxybuprocaine and proxymetacaine produced more potent spinal blockades, when compared with bupivacaine or lidocaine. Oxybuprocaine and bupivacaine with a more sensory-selective action over motor blockade produced longer spinal blockade than did proxymetacaine or lidocaine.

原文English
頁(從 - 到)249-253
頁數5
期刊Neuroscience Letters
454
發行號3
DOIs
出版狀態Published - 2009 五月 1

指紋

benoxinate
Spinal Anesthesia
Bupivacaine
Lidocaine
Proprioception
Nociception
proxymetacaine

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

引用此文

Hung, Ching-Hsia ; Wang, Jhi Joung ; Chen, Yu Chung ; Chu, Chin Chen ; Chen, Yu Wen. / Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. 於: Neuroscience Letters. 2009 ; 卷 454, 編號 3. 頁 249-253.
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abstract = "Proxymetacaine and oxybuprocaine were clinically used for topical ocular anesthesia but never for spinal anesthesia, and therefore spinal anesthetic effects of proxymetacaine and oxybuprocaine were performed and compared with bupivacaine and lidocaine. After rats were injected intrathecally with proxymetacaine, oxybuprocaine, bupivacaine, and lidocane, dose-response curves were constructed. We evaluated the potencies (ED50) and durations (time to full recovery) of proxymetacaine and oxybuprocaine on spinal blockades of motor function, proprioception, and nociception and compared with bupivacaine and lidocaine in rats. We found that proxymetacaine and oxybuprocaine acted like bupivacaine or lidocaine and produced dose-related spinal blockades of motor function, proprioception and nociception. On the ED50 basis, the ranks of potencies in motor, proprioception, and nociception were proxymetacaine > oxybuprocaine > bupivacaine > lidocaine (P < 0.01 for the differences). On an equipotent basis (ED20, ED50, ED80), oxybuprocaine and bupivacaine produced similarly longer spinal blockades than did proxymetacaine or lidocaine (P < 0.05 for the differences). Intrathecal proxymetacaine, oxybuprocaine, and bupivacaine also produced longer sensory blockade than motor blockade. These data demonstrated that oxybuprocaine and proxymetacaine produced more potent spinal blockades, when compared with bupivacaine or lidocaine. Oxybuprocaine and bupivacaine with a more sensory-selective action over motor blockade produced longer spinal blockade than did proxymetacaine or lidocaine.",
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Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. / Hung, Ching-Hsia; Wang, Jhi Joung; Chen, Yu Chung; Chu, Chin Chen; Chen, Yu Wen.

於: Neuroscience Letters, 卷 454, 編號 3, 01.05.2009, p. 249-253.

研究成果: Article

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T1 - Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats

AU - Hung, Ching-Hsia

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AU - Chen, Yu Wen

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AB - Proxymetacaine and oxybuprocaine were clinically used for topical ocular anesthesia but never for spinal anesthesia, and therefore spinal anesthetic effects of proxymetacaine and oxybuprocaine were performed and compared with bupivacaine and lidocaine. After rats were injected intrathecally with proxymetacaine, oxybuprocaine, bupivacaine, and lidocane, dose-response curves were constructed. We evaluated the potencies (ED50) and durations (time to full recovery) of proxymetacaine and oxybuprocaine on spinal blockades of motor function, proprioception, and nociception and compared with bupivacaine and lidocaine in rats. We found that proxymetacaine and oxybuprocaine acted like bupivacaine or lidocaine and produced dose-related spinal blockades of motor function, proprioception and nociception. On the ED50 basis, the ranks of potencies in motor, proprioception, and nociception were proxymetacaine > oxybuprocaine > bupivacaine > lidocaine (P < 0.01 for the differences). On an equipotent basis (ED20, ED50, ED80), oxybuprocaine and bupivacaine produced similarly longer spinal blockades than did proxymetacaine or lidocaine (P < 0.05 for the differences). Intrathecal proxymetacaine, oxybuprocaine, and bupivacaine also produced longer sensory blockade than motor blockade. These data demonstrated that oxybuprocaine and proxymetacaine produced more potent spinal blockades, when compared with bupivacaine or lidocaine. Oxybuprocaine and bupivacaine with a more sensory-selective action over motor blockade produced longer spinal blockade than did proxymetacaine or lidocaine.

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