Intrathecal pramoxine causes long-lasting spinal sensory and motor block in rats

An Kuo Chou, Chong Chi Chiu, Ming Ming Han, Yu Wen Chen, Jhi Joung Wang, Ching-Hsia Hung

研究成果: Article

2 引文 (Scopus)

摘要

Objectives: The objective of this experiment was to investigate spinal anaesthetic effects of pramoxine and its comparison with bupivacaine, a long-lasting local anaesthetic. Methods: After intrathecal injection, three neurobehavioural assessments, which consisted of nociceptive, proprioceptive and motor block, were constructed in rats. The effects of bupivacaine and pramoxine (four doses of each drug) in a dose-related manner were conducted to obtain the ED50 (50% effective dose). Pramoxine potency and duration at provoking spinal nociceptive, proprioceptive and motor block were compared with those of bupivacaine. Key findings: We manifested that pramoxine provoked dose-relatedly spinal blockades of nociception, proprioception and motor function. Based on the ED50, the rank potency at producing spinal nociceptive, proprioceptive and motor block was bupivacaine (0.90 (0.82–1.02), 1.00 (0.92–1.08) and 1.16 (1.02–1.34) μmol/kg) greater (P < 0.01 for the differences) than pramoxine (15.47 (14.04–17.05), 16.46 (15.06–17.99), and 17.77 (16.48–19.15) μmol/kg). The spinal block duration created by bupivacaine was not predominantly different (P > 0.05 for the differences) from that created by pramoxine at the equipotent doses (ED75, ED50 and ED25). Conclusions: Our preclinical experiment indicated that pramoxine elicited a dose-related spinal block, was less potent than bupivacaine and had a similar duration of spinal block compared with bupivacaine.

原文English
頁(從 - 到)543-549
頁數7
期刊Journal of Pharmacy and Pharmacology
70
發行號4
DOIs
出版狀態Published - 2018 四月 1

指紋

Bupivacaine
Proprioception
Spinal Injections
Nociception
Local Anesthetics
Anesthetics
pramoxine
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

引用此文

Chou, An Kuo ; Chiu, Chong Chi ; Han, Ming Ming ; Chen, Yu Wen ; Wang, Jhi Joung ; Hung, Ching-Hsia. / Intrathecal pramoxine causes long-lasting spinal sensory and motor block in rats. 於: Journal of Pharmacy and Pharmacology. 2018 ; 卷 70, 編號 4. 頁 543-549.
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abstract = "Objectives: The objective of this experiment was to investigate spinal anaesthetic effects of pramoxine and its comparison with bupivacaine, a long-lasting local anaesthetic. Methods: After intrathecal injection, three neurobehavioural assessments, which consisted of nociceptive, proprioceptive and motor block, were constructed in rats. The effects of bupivacaine and pramoxine (four doses of each drug) in a dose-related manner were conducted to obtain the ED50 (50{\%} effective dose). Pramoxine potency and duration at provoking spinal nociceptive, proprioceptive and motor block were compared with those of bupivacaine. Key findings: We manifested that pramoxine provoked dose-relatedly spinal blockades of nociception, proprioception and motor function. Based on the ED50, the rank potency at producing spinal nociceptive, proprioceptive and motor block was bupivacaine (0.90 (0.82–1.02), 1.00 (0.92–1.08) and 1.16 (1.02–1.34) μmol/kg) greater (P < 0.01 for the differences) than pramoxine (15.47 (14.04–17.05), 16.46 (15.06–17.99), and 17.77 (16.48–19.15) μmol/kg). The spinal block duration created by bupivacaine was not predominantly different (P > 0.05 for the differences) from that created by pramoxine at the equipotent doses (ED75, ED50 and ED25). Conclusions: Our preclinical experiment indicated that pramoxine elicited a dose-related spinal block, was less potent than bupivacaine and had a similar duration of spinal block compared with bupivacaine.",
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Intrathecal pramoxine causes long-lasting spinal sensory and motor block in rats. / Chou, An Kuo; Chiu, Chong Chi; Han, Ming Ming; Chen, Yu Wen; Wang, Jhi Joung; Hung, Ching-Hsia.

於: Journal of Pharmacy and Pharmacology, 卷 70, 編號 4, 01.04.2018, p. 543-549.

研究成果: Article

TY - JOUR

T1 - Intrathecal pramoxine causes long-lasting spinal sensory and motor block in rats

AU - Chou, An Kuo

AU - Chiu, Chong Chi

AU - Han, Ming Ming

AU - Chen, Yu Wen

AU - Wang, Jhi Joung

AU - Hung, Ching-Hsia

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Objectives: The objective of this experiment was to investigate spinal anaesthetic effects of pramoxine and its comparison with bupivacaine, a long-lasting local anaesthetic. Methods: After intrathecal injection, three neurobehavioural assessments, which consisted of nociceptive, proprioceptive and motor block, were constructed in rats. The effects of bupivacaine and pramoxine (four doses of each drug) in a dose-related manner were conducted to obtain the ED50 (50% effective dose). Pramoxine potency and duration at provoking spinal nociceptive, proprioceptive and motor block were compared with those of bupivacaine. Key findings: We manifested that pramoxine provoked dose-relatedly spinal blockades of nociception, proprioception and motor function. Based on the ED50, the rank potency at producing spinal nociceptive, proprioceptive and motor block was bupivacaine (0.90 (0.82–1.02), 1.00 (0.92–1.08) and 1.16 (1.02–1.34) μmol/kg) greater (P < 0.01 for the differences) than pramoxine (15.47 (14.04–17.05), 16.46 (15.06–17.99), and 17.77 (16.48–19.15) μmol/kg). The spinal block duration created by bupivacaine was not predominantly different (P > 0.05 for the differences) from that created by pramoxine at the equipotent doses (ED75, ED50 and ED25). Conclusions: Our preclinical experiment indicated that pramoxine elicited a dose-related spinal block, was less potent than bupivacaine and had a similar duration of spinal block compared with bupivacaine.

AB - Objectives: The objective of this experiment was to investigate spinal anaesthetic effects of pramoxine and its comparison with bupivacaine, a long-lasting local anaesthetic. Methods: After intrathecal injection, three neurobehavioural assessments, which consisted of nociceptive, proprioceptive and motor block, were constructed in rats. The effects of bupivacaine and pramoxine (four doses of each drug) in a dose-related manner were conducted to obtain the ED50 (50% effective dose). Pramoxine potency and duration at provoking spinal nociceptive, proprioceptive and motor block were compared with those of bupivacaine. Key findings: We manifested that pramoxine provoked dose-relatedly spinal blockades of nociception, proprioception and motor function. Based on the ED50, the rank potency at producing spinal nociceptive, proprioceptive and motor block was bupivacaine (0.90 (0.82–1.02), 1.00 (0.92–1.08) and 1.16 (1.02–1.34) μmol/kg) greater (P < 0.01 for the differences) than pramoxine (15.47 (14.04–17.05), 16.46 (15.06–17.99), and 17.77 (16.48–19.15) μmol/kg). The spinal block duration created by bupivacaine was not predominantly different (P > 0.05 for the differences) from that created by pramoxine at the equipotent doses (ED75, ED50 and ED25). Conclusions: Our preclinical experiment indicated that pramoxine elicited a dose-related spinal block, was less potent than bupivacaine and had a similar duration of spinal block compared with bupivacaine.

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