Introduction to a Thematic Issue for WWOX

Nan Shan Chang

研究成果: Article同行評審

14 引文 斯高帕斯(Scopus)

摘要

Since its discovery in 2000, WW domain-containing oxidoreductase (WWOX, FOR or WOX1) has been considered as a tumor suppressor protein. Global research focus has been aimed mainly toward this direction. In this thematic issue, updated information has been collected regarding the structure, function and signaling of WWOX, along with its critical role as a tumor suppressor and participation in metabolism, neurodegeneration, ataxia, epilepsy, neural disorders, neuronal damages, and interactions with oncogenic viruses. WWOX is not a driver of cancer initiation. Chromosomal alterations in the WWOX gene enhance cancer progression. Importantly, a homozygous nonsense mutation of WWOX gene in humans leads to neural pathologies and early death, rather than spontaneous cancer development. These findings suggest new physiological functions of WWOX in metabolism and neural diseases, and these areas require further investigation.

原文English
頁(從 - 到)281-284
頁數4
期刊Experimental Biology and Medicine
240
發行號3
DOIs
出版狀態Published - 2015 3月 25

All Science Journal Classification (ASJC) codes

  • 一般生物化學,遺傳學和分子生物學

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