Investigating the association between oral hygiene and head and neck cancer

Jeffrey S. Chang, Hung I. Lo, Tung Yiu Wong, Cheng Chih Huang, Wei Ting Lee, Sen Tien Tsai, Ken Chung Chen, Chia Jui Yen, Yuan Hua Wu, Wei Ting Hsueh, Ming Wei Yang, Shang Yin Wu, Kwang Yu Chang, Jang Yang Chang, Chun Yen Ou, Yi Hui Wang, Ya Ling Weng, Han Chien Yang, Fang Ting Wang, Chen Lin LinJehn Shyun Huang, Jenn Ren Hsiao

研究成果: Article

48 引文 (Scopus)

摘要

Objectives: This analysis examined the association between oral hygiene and head and neck cancer (HNC) and whether this association differed by the consumption of alcohol, betel quid, or cigarette and by the genetic polymorphisms of inflammation-related genes. Materials and methods: Interviews regarding dental care and oral health were conducted with 317 HNC cases and 296 controls. Genotyping was performed for 6 single nucleotide polymorphisms in IL6, IL10 and PTGS2. Results: A positive association was observed between HNC and no regular dental visits (odds ratio (OR) = 2.86, 95% confidence interval (CI): 1.47-5.57), brushing teeth <2 times/day (OR = 1.51, 95% CI: 1.02-2.23), frequent gum bleeding (OR = 3.15, 95% CI: 1.36-7.28), and loss of >20 teeth (OR = 2.31, 95% CI: 1.05-5.07). Analysis with dental care score (range: 0-4, 4 = worst dental care), which combined regular dental visits, toothbrushing, and use of dental floss and mouthwash, showed a positive trend with HNC risk, particularly among alcohol drinkers and cigarette smokers. Multifactor dimensionality reduction analysis divided the study subjects into high- and low-risk group based on combinations of dental care score and IL6 rs1800796 genotypes. Compared to the low-risk group, the high-risk group had an OR of HNC = 2.16 (95% CI: 1.44-3.25). Conclusions: This study observed a positive association between poor oral hygiene and HNC, which appeared to differ by alcohol or cigarette consumption and the genotypes of IL6 rs1800796. Further investigations are needed to determine whether poor oral hygiene is a cause for HNC or a surrogatemarker of an unhealthy lifestyle that increases the risk of HNC.

原文English
頁(從 - 到)1010-1017
頁數8
期刊Oral Oncology
49
發行號10
DOIs
出版狀態Published - 2013 十月 1

指紋

Oral Hygiene
Head and Neck Neoplasms
Dental Care
Tooth
Tobacco Products
Interleukin-6
Odds Ratio
Confidence Intervals
Home Care Dental Devices
Multifactor Dimensionality Reduction
Genotype
Alcohols
Mouthwashes
Toothbrushing
Oral Health
Genetic Polymorphisms
Cyclooxygenase 2
Alcohol Drinking
Interleukin-10
Single Nucleotide Polymorphism

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

引用此文

@article{ee6695188f2d48e3bfba8af74e5bab87,
title = "Investigating the association between oral hygiene and head and neck cancer",
abstract = "Objectives: This analysis examined the association between oral hygiene and head and neck cancer (HNC) and whether this association differed by the consumption of alcohol, betel quid, or cigarette and by the genetic polymorphisms of inflammation-related genes. Materials and methods: Interviews regarding dental care and oral health were conducted with 317 HNC cases and 296 controls. Genotyping was performed for 6 single nucleotide polymorphisms in IL6, IL10 and PTGS2. Results: A positive association was observed between HNC and no regular dental visits (odds ratio (OR) = 2.86, 95{\%} confidence interval (CI): 1.47-5.57), brushing teeth <2 times/day (OR = 1.51, 95{\%} CI: 1.02-2.23), frequent gum bleeding (OR = 3.15, 95{\%} CI: 1.36-7.28), and loss of >20 teeth (OR = 2.31, 95{\%} CI: 1.05-5.07). Analysis with dental care score (range: 0-4, 4 = worst dental care), which combined regular dental visits, toothbrushing, and use of dental floss and mouthwash, showed a positive trend with HNC risk, particularly among alcohol drinkers and cigarette smokers. Multifactor dimensionality reduction analysis divided the study subjects into high- and low-risk group based on combinations of dental care score and IL6 rs1800796 genotypes. Compared to the low-risk group, the high-risk group had an OR of HNC = 2.16 (95{\%} CI: 1.44-3.25). Conclusions: This study observed a positive association between poor oral hygiene and HNC, which appeared to differ by alcohol or cigarette consumption and the genotypes of IL6 rs1800796. Further investigations are needed to determine whether poor oral hygiene is a cause for HNC or a surrogatemarker of an unhealthy lifestyle that increases the risk of HNC.",
author = "Chang, {Jeffrey S.} and Lo, {Hung I.} and Wong, {Tung Yiu} and Huang, {Cheng Chih} and Lee, {Wei Ting} and Tsai, {Sen Tien} and Chen, {Ken Chung} and Yen, {Chia Jui} and Wu, {Yuan Hua} and Hsueh, {Wei Ting} and Yang, {Ming Wei} and Wu, {Shang Yin} and Chang, {Kwang Yu} and Chang, {Jang Yang} and Ou, {Chun Yen} and Wang, {Yi Hui} and Weng, {Ya Ling} and Yang, {Han Chien} and Wang, {Fang Ting} and Lin, {Chen Lin} and Huang, {Jehn Shyun} and Hsiao, {Jenn Ren}",
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Investigating the association between oral hygiene and head and neck cancer. / Chang, Jeffrey S.; Lo, Hung I.; Wong, Tung Yiu; Huang, Cheng Chih; Lee, Wei Ting; Tsai, Sen Tien; Chen, Ken Chung; Yen, Chia Jui; Wu, Yuan Hua; Hsueh, Wei Ting; Yang, Ming Wei; Wu, Shang Yin; Chang, Kwang Yu; Chang, Jang Yang; Ou, Chun Yen; Wang, Yi Hui; Weng, Ya Ling; Yang, Han Chien; Wang, Fang Ting; Lin, Chen Lin; Huang, Jehn Shyun; Hsiao, Jenn Ren.

於: Oral Oncology, 卷 49, 編號 10, 01.10.2013, p. 1010-1017.

研究成果: Article

TY - JOUR

T1 - Investigating the association between oral hygiene and head and neck cancer

AU - Chang, Jeffrey S.

AU - Lo, Hung I.

AU - Wong, Tung Yiu

AU - Huang, Cheng Chih

AU - Lee, Wei Ting

AU - Tsai, Sen Tien

AU - Chen, Ken Chung

AU - Yen, Chia Jui

AU - Wu, Yuan Hua

AU - Hsueh, Wei Ting

AU - Yang, Ming Wei

AU - Wu, Shang Yin

AU - Chang, Kwang Yu

AU - Chang, Jang Yang

AU - Ou, Chun Yen

AU - Wang, Yi Hui

AU - Weng, Ya Ling

AU - Yang, Han Chien

AU - Wang, Fang Ting

AU - Lin, Chen Lin

AU - Huang, Jehn Shyun

AU - Hsiao, Jenn Ren

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Objectives: This analysis examined the association between oral hygiene and head and neck cancer (HNC) and whether this association differed by the consumption of alcohol, betel quid, or cigarette and by the genetic polymorphisms of inflammation-related genes. Materials and methods: Interviews regarding dental care and oral health were conducted with 317 HNC cases and 296 controls. Genotyping was performed for 6 single nucleotide polymorphisms in IL6, IL10 and PTGS2. Results: A positive association was observed between HNC and no regular dental visits (odds ratio (OR) = 2.86, 95% confidence interval (CI): 1.47-5.57), brushing teeth <2 times/day (OR = 1.51, 95% CI: 1.02-2.23), frequent gum bleeding (OR = 3.15, 95% CI: 1.36-7.28), and loss of >20 teeth (OR = 2.31, 95% CI: 1.05-5.07). Analysis with dental care score (range: 0-4, 4 = worst dental care), which combined regular dental visits, toothbrushing, and use of dental floss and mouthwash, showed a positive trend with HNC risk, particularly among alcohol drinkers and cigarette smokers. Multifactor dimensionality reduction analysis divided the study subjects into high- and low-risk group based on combinations of dental care score and IL6 rs1800796 genotypes. Compared to the low-risk group, the high-risk group had an OR of HNC = 2.16 (95% CI: 1.44-3.25). Conclusions: This study observed a positive association between poor oral hygiene and HNC, which appeared to differ by alcohol or cigarette consumption and the genotypes of IL6 rs1800796. Further investigations are needed to determine whether poor oral hygiene is a cause for HNC or a surrogatemarker of an unhealthy lifestyle that increases the risk of HNC.

AB - Objectives: This analysis examined the association between oral hygiene and head and neck cancer (HNC) and whether this association differed by the consumption of alcohol, betel quid, or cigarette and by the genetic polymorphisms of inflammation-related genes. Materials and methods: Interviews regarding dental care and oral health were conducted with 317 HNC cases and 296 controls. Genotyping was performed for 6 single nucleotide polymorphisms in IL6, IL10 and PTGS2. Results: A positive association was observed between HNC and no regular dental visits (odds ratio (OR) = 2.86, 95% confidence interval (CI): 1.47-5.57), brushing teeth <2 times/day (OR = 1.51, 95% CI: 1.02-2.23), frequent gum bleeding (OR = 3.15, 95% CI: 1.36-7.28), and loss of >20 teeth (OR = 2.31, 95% CI: 1.05-5.07). Analysis with dental care score (range: 0-4, 4 = worst dental care), which combined regular dental visits, toothbrushing, and use of dental floss and mouthwash, showed a positive trend with HNC risk, particularly among alcohol drinkers and cigarette smokers. Multifactor dimensionality reduction analysis divided the study subjects into high- and low-risk group based on combinations of dental care score and IL6 rs1800796 genotypes. Compared to the low-risk group, the high-risk group had an OR of HNC = 2.16 (95% CI: 1.44-3.25). Conclusions: This study observed a positive association between poor oral hygiene and HNC, which appeared to differ by alcohol or cigarette consumption and the genotypes of IL6 rs1800796. Further investigations are needed to determine whether poor oral hygiene is a cause for HNC or a surrogatemarker of an unhealthy lifestyle that increases the risk of HNC.

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U2 - 10.1016/j.oraloncology.2013.07.004

DO - 10.1016/j.oraloncology.2013.07.004

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AN - SCOPUS:84884283034

VL - 49

SP - 1010

EP - 1017

JO - Oral Oncology

JF - Oral Oncology

SN - 1368-8375

IS - 10

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