Investigating the role of Sirt1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson's disease

Kun Ling Tsai, Yuan Yang Cheng, Hsin Bang Leu, Yi Yen Lee, Tzeng Ji Chen, Ding Hao Liu, Chung Lan Kao

研究成果: Article同行評審

33 引文 斯高帕斯(Scopus)

摘要

Benign paroxysmal positional vertigo (BPPV) is one of the most frequently encountered primary complaints in dizziness clinics. The incidence of BPPV has been proven to increase with age. The relationship between BPPV and another neurodegenerative disease, Parkinson's disease (PD), has not been previously discussed. This study aimed to investigate the relationship of BPPV and PD with oxidative stress. A total of 30,811 subjects participated in our cohort study. The study cohort comprised 5057 BPPV patients and a comparison cohort of 25,754 nonBPPV patients. SIRT1 axis gene expression was investigated in BPPV patient blood samples and a PD cell model of 6-hydroxydopamine (6-OHDA)-treated PC-12 cells to elucidate the potential invitro and invivo mechanisms of degeneration in PD and BPPV. Our data suggest that BPPV patients with histories of head injuries show a significantly higher hazard to develop subsequent PD (hazard ratio, 3.942; confidence interval, 1.523-10.205, p= 0.005). We also observed that oxidative status is increased in blood samples from patients with BPPV. Our invitro study suggests that SIRT1 function is inhibited by oxidative stress, which thereby promotes 6-hydroxydopamine-induced cell death. We conclude that BPPV is independently associated with an increased risk of PD. This finding may be attributed to oxidative stress-mediated inhibition of SIRT1 expression levels.

原文English
頁(從 - 到)2607-2616
頁數10
期刊Neurobiology of Aging
36
發行號9
DOIs
出版狀態Published - 2015 9月 1

All Science Journal Classification (ASJC) codes

  • 一般神經科學
  • 老化
  • 發展生物學
  • 神經病學(臨床)
  • 老年病學和老年學

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