Investigation of neuropathology after nerve release in chronic constriction injury of rat sciatic nerve

Szu Han Chen, Chia Ching Wu, Sheng Che Lin, Wan Ling Tseng, Tzu Chieh Huang, Anjali Yadav, Fu I. Lu, Ya Hsin Liu, Shau Ping Lin, Yuan Yu Hsueh

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

Peripheral compressive neuropathy causes significant neuropathic pain, muscle weakness and prolong neuroinflammation. Surgical decompression remains the gold standard of treatment but the outcome is suboptimal with a high recurrence rate. From mechanical compression to chemical propagation of the local inflammatory signals, little is known about the distinct neuropathologic patterns and the genetic signatures after nerve decompression. In this study, controllable mechanical constriction forces over rat sciatic nerve induces irreversible sensorimotor dysfunction with sustained local neuroinflammation, even 4 weeks after nerve release. Significant gene upregulations are found in the dorsal root ganglia, regarding inflammatory, proapoptotic and neuropathic pain signals. Genetic profiling of neuroinflammation at the local injured nerve reveals persistent upregulation of multiple genes involving oxysterol metabolism, neuronal apoptosis, and proliferation after nerve release. Further validation of the independent roles of each signal pathway will contribute to molecular therapies for compressive neuropathy in the future.

原文English
文章編號4746
期刊International journal of molecular sciences
22
發行號9
DOIs
出版狀態Published - 2021 5月 1

All Science Journal Classification (ASJC) codes

  • 催化
  • 分子生物學
  • 光譜
  • 電腦科學應用
  • 物理與理論化學
  • 有機化學
  • 無機化學

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