Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy

Chao Chun Yang, Yun Yo Yen, Chao Kai Hsu, Nan Yu Cheng, Shih Yu Tzeng, Shih Jay Chou, Jun Ming Chang, Sheng Hao Tseng

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)


Psoriasis affects more than 125 million people worldwide, and the diagnosis and treatment efficacy evaluation of the disease mainly rely on clinical assessments that could be subjective. Our previous study showed that the skin erythema level could be quantified using diffuse reflectance spectroscopy (DRS), and the hemoglobin concentration of most psoriatic lesion was higher than that of its adjacent uninvolved skin. While the compromised epidermal barrier function has been taken as the major cause of clinical manifestation of skin dryness and inflammation of psoriasis, very few methods can be used to effectively evaluate this function. In this study, we investigate the near infrared spectroscopic features of psoriatic (n = 21) and normal (n = 21) skin that could link to the epidermal barrier function. From the DRS measurements, it was found that the water bonding status and light scattering properties of psoriasis are significantly different from those of uninvolved or normal skin. The connection between these parameters to the epidermal barrier function and morphology will be discussed. Our results suggest that objective evaluation of epidermal barrier function of psoriasis could be achieved using a simple DRS system.

頁(從 - 到)8901
期刊Scientific reports
出版狀態Published - 2021 4月 26

All Science Journal Classification (ASJC) codes

  • 多學科


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