Investigations of clinical isolations of oral poliovirus vaccine strains between 2000 and 2005 in southern Taiwan

Chia Yu Chi, Fan Chen Tseng, Ding Ping Liu, Ya Wen Chang, Han Chieh Wu, Yung Feng Huang, Kao Pin Hwang, Yun Wei Hsu, Shih-Min Wang, Ching-Chuan Liu, Ho Sheng Wu, Jyh Yuan Yang, Chen Fu Yang, Jen-Ren Wang, Ih Jen Su

研究成果: Article

3 引文 (Scopus)

摘要

Background: In Taiwan, trivalent oral poliovirus vaccine (tOPV) is in the routine immunization schedule, but its association with illnesses had not been examined. Objectives: To investigate clinical presentations and viral characteristics of patients with poliovirus isolates. Study design: Clinical data, vaccination records and viral sequences were retrospectively analyzed for patients from whom polioviruses were isolated during 2000-2005. Results: OPV-like strains were the only pathogen identified in 208 children who were diagnosed with lower respiratory tract infection (24.5%), acute gastroenteritis (16.8%) or upper respiratory tract infection (10.6%). Timing of poliovirus isolation relative to the tOPV vaccination was unusual in 59 patients, including 6 before any dose and 53 more than 10 weeks after the 3rd or later dose of tOPV. Sequence analyses of the VP1, 2C and 3C/D regions for 19 poliovirus isolates revealed that 4 had previously reported neurovirulence reversions, 1 had intertypic recombination, and 6 had both. No patient had neurological complications, but 3 died of myocarditis, including 2 with recombinant strains and 1 who never received OPV. Conclusion: This study describes the isolation of OPV-like strains from patients with a variety of illnesses, raising concerns about their pathogenic potential in an area where tOPV is routinely administered. The detection of genetic variations among OPV-like strains warrants continuing surveillance for these variants in patients with severe illnesses besides neurological complications.

原文English
頁(從 - 到)129-134
頁數6
期刊Journal of Clinical Virology
45
發行號2
DOIs
出版狀態Published - 2009 六月 1

指紋

Oral Poliovirus Vaccine
Taiwan
Poliovirus
Respiratory Tract Infections
Vaccination
Immunization Schedule
Myocarditis
Gastroenteritis
Genetic Recombination
Sequence Analysis

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

引用此文

Chi, Chia Yu ; Tseng, Fan Chen ; Liu, Ding Ping ; Chang, Ya Wen ; Wu, Han Chieh ; Huang, Yung Feng ; Hwang, Kao Pin ; Hsu, Yun Wei ; Wang, Shih-Min ; Liu, Ching-Chuan ; Wu, Ho Sheng ; Yang, Jyh Yuan ; Yang, Chen Fu ; Wang, Jen-Ren ; Su, Ih Jen. / Investigations of clinical isolations of oral poliovirus vaccine strains between 2000 and 2005 in southern Taiwan. 於: Journal of Clinical Virology. 2009 ; 卷 45, 編號 2. 頁 129-134.
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title = "Investigations of clinical isolations of oral poliovirus vaccine strains between 2000 and 2005 in southern Taiwan",
abstract = "Background: In Taiwan, trivalent oral poliovirus vaccine (tOPV) is in the routine immunization schedule, but its association with illnesses had not been examined. Objectives: To investigate clinical presentations and viral characteristics of patients with poliovirus isolates. Study design: Clinical data, vaccination records and viral sequences were retrospectively analyzed for patients from whom polioviruses were isolated during 2000-2005. Results: OPV-like strains were the only pathogen identified in 208 children who were diagnosed with lower respiratory tract infection (24.5{\%}), acute gastroenteritis (16.8{\%}) or upper respiratory tract infection (10.6{\%}). Timing of poliovirus isolation relative to the tOPV vaccination was unusual in 59 patients, including 6 before any dose and 53 more than 10 weeks after the 3rd or later dose of tOPV. Sequence analyses of the VP1, 2C and 3C/D regions for 19 poliovirus isolates revealed that 4 had previously reported neurovirulence reversions, 1 had intertypic recombination, and 6 had both. No patient had neurological complications, but 3 died of myocarditis, including 2 with recombinant strains and 1 who never received OPV. Conclusion: This study describes the isolation of OPV-like strains from patients with a variety of illnesses, raising concerns about their pathogenic potential in an area where tOPV is routinely administered. The detection of genetic variations among OPV-like strains warrants continuing surveillance for these variants in patients with severe illnesses besides neurological complications.",
author = "Chi, {Chia Yu} and Tseng, {Fan Chen} and Liu, {Ding Ping} and Chang, {Ya Wen} and Wu, {Han Chieh} and Huang, {Yung Feng} and Hwang, {Kao Pin} and Hsu, {Yun Wei} and Shih-Min Wang and Ching-Chuan Liu and Wu, {Ho Sheng} and Yang, {Jyh Yuan} and Yang, {Chen Fu} and Jen-Ren Wang and Su, {Ih Jen}",
year = "2009",
month = "6",
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doi = "10.1016/j.jcv.2009.03.013",
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Chi, CY, Tseng, FC, Liu, DP, Chang, YW, Wu, HC, Huang, YF, Hwang, KP, Hsu, YW, Wang, S-M, Liu, C-C, Wu, HS, Yang, JY, Yang, CF, Wang, J-R & Su, IJ 2009, 'Investigations of clinical isolations of oral poliovirus vaccine strains between 2000 and 2005 in southern Taiwan', Journal of Clinical Virology, 卷 45, 編號 2, 頁 129-134. https://doi.org/10.1016/j.jcv.2009.03.013

Investigations of clinical isolations of oral poliovirus vaccine strains between 2000 and 2005 in southern Taiwan. / Chi, Chia Yu; Tseng, Fan Chen; Liu, Ding Ping; Chang, Ya Wen; Wu, Han Chieh; Huang, Yung Feng; Hwang, Kao Pin; Hsu, Yun Wei; Wang, Shih-Min; Liu, Ching-Chuan; Wu, Ho Sheng; Yang, Jyh Yuan; Yang, Chen Fu; Wang, Jen-Ren; Su, Ih Jen.

於: Journal of Clinical Virology, 卷 45, 編號 2, 01.06.2009, p. 129-134.

研究成果: Article

TY - JOUR

T1 - Investigations of clinical isolations of oral poliovirus vaccine strains between 2000 and 2005 in southern Taiwan

AU - Chi, Chia Yu

AU - Tseng, Fan Chen

AU - Liu, Ding Ping

AU - Chang, Ya Wen

AU - Wu, Han Chieh

AU - Huang, Yung Feng

AU - Hwang, Kao Pin

AU - Hsu, Yun Wei

AU - Wang, Shih-Min

AU - Liu, Ching-Chuan

AU - Wu, Ho Sheng

AU - Yang, Jyh Yuan

AU - Yang, Chen Fu

AU - Wang, Jen-Ren

AU - Su, Ih Jen

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Background: In Taiwan, trivalent oral poliovirus vaccine (tOPV) is in the routine immunization schedule, but its association with illnesses had not been examined. Objectives: To investigate clinical presentations and viral characteristics of patients with poliovirus isolates. Study design: Clinical data, vaccination records and viral sequences were retrospectively analyzed for patients from whom polioviruses were isolated during 2000-2005. Results: OPV-like strains were the only pathogen identified in 208 children who were diagnosed with lower respiratory tract infection (24.5%), acute gastroenteritis (16.8%) or upper respiratory tract infection (10.6%). Timing of poliovirus isolation relative to the tOPV vaccination was unusual in 59 patients, including 6 before any dose and 53 more than 10 weeks after the 3rd or later dose of tOPV. Sequence analyses of the VP1, 2C and 3C/D regions for 19 poliovirus isolates revealed that 4 had previously reported neurovirulence reversions, 1 had intertypic recombination, and 6 had both. No patient had neurological complications, but 3 died of myocarditis, including 2 with recombinant strains and 1 who never received OPV. Conclusion: This study describes the isolation of OPV-like strains from patients with a variety of illnesses, raising concerns about their pathogenic potential in an area where tOPV is routinely administered. The detection of genetic variations among OPV-like strains warrants continuing surveillance for these variants in patients with severe illnesses besides neurological complications.

AB - Background: In Taiwan, trivalent oral poliovirus vaccine (tOPV) is in the routine immunization schedule, but its association with illnesses had not been examined. Objectives: To investigate clinical presentations and viral characteristics of patients with poliovirus isolates. Study design: Clinical data, vaccination records and viral sequences were retrospectively analyzed for patients from whom polioviruses were isolated during 2000-2005. Results: OPV-like strains were the only pathogen identified in 208 children who were diagnosed with lower respiratory tract infection (24.5%), acute gastroenteritis (16.8%) or upper respiratory tract infection (10.6%). Timing of poliovirus isolation relative to the tOPV vaccination was unusual in 59 patients, including 6 before any dose and 53 more than 10 weeks after the 3rd or later dose of tOPV. Sequence analyses of the VP1, 2C and 3C/D regions for 19 poliovirus isolates revealed that 4 had previously reported neurovirulence reversions, 1 had intertypic recombination, and 6 had both. No patient had neurological complications, but 3 died of myocarditis, including 2 with recombinant strains and 1 who never received OPV. Conclusion: This study describes the isolation of OPV-like strains from patients with a variety of illnesses, raising concerns about their pathogenic potential in an area where tOPV is routinely administered. The detection of genetic variations among OPV-like strains warrants continuing surveillance for these variants in patients with severe illnesses besides neurological complications.

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