Isolation and Identification of a Novel Antioxidant with Antitumour Activity from Serratia ureilytica Using Squid Pen as Fermentation Substrate

Yao Haur Kuo, Tzu Wen Liang, Kao Cheng Liu, Ya Wen Hsu, Hsiu Ching Hsu, San Lang Wang

研究成果: Article同行評審

24 引文 斯高帕斯(Scopus)

摘要

The antioxidant activity of the culture supernatant of Serratia ureilytica TKU013 with squid pen as the sole carbon/nitrogen source was assessed by three methods, and the phenolic contents were assayed. The supernatant with the highest antioxidant activity was further purified by liquid-liquid partition, revealing the ethyl acetate extract exhibited the strongest antioxidant activity and the highest total phenolic content. Eight fractions were retrieved from silica gel column chromatography of this extract, designated F1-F8. F4 was found to possess the strong antioxidative activity and the highest total phenolic content and also exhibited strong cytotoxic activities against two different tumoural cell lines. A new compound (Serranticin) with antioxidant and antitumor activity was obtained from F4. The structure of Serranticin is analogous to that of siderophores (hexacoordinated catecholamine), which are iron chelators. As such, Serranticin has the potential for use as a deferration agent in various iron overload diseases.

原文English
頁(從 - 到)451-461
頁數11
期刊Marine Biotechnology
13
發行號3
DOIs
出版狀態Published - 2011 六月

All Science Journal Classification (ASJC) codes

  • 生物技術
  • 海洋科學

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