Isolation and identification of antiplatelet aggregatory principles from the leaves of Piper lolot

Chia Ying Li, Wei Jern Tsai, Amooru Gangaiah Damu, E. Jian Lee, Tian Shung Wu, Xuan Dung Nguyen, Dinh Thang Tran, Le Thanh

研究成果: Article同行評審

24 引文 斯高帕斯(Scopus)

摘要

The methanolic extract of Piper lolot, having shown potent inhibitory activity on platelet aggregation induced by arachidonic acid (AA) and platelet activating factor (PAF), was subjected to activity-guided isolation to yield twelve new amide alkaloids, piperlotine A-L (1-12), along with twenty-nine known compounds. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were tested for their inhibitory activity on the rabbit platelet aggregation. The compounds piperlotine A (1), piperlotine C (3), piperlotine D (4), piperlotine E (5), 3-phenyl-1-(2,4,6-trihydroxyphenyl) propan-1-one (21), 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one (22), 1-trans-cinnamoylpyrrolidine (24), sarmentine (26), pellitorine (27), methyl 3-phenylpropionate (32), and (10S)-10-hydroxypheophorbide a methyl ester (40) showed potent antiplatelet aggregation activity.

原文English
頁(從 - 到)9436-9442
頁數7
期刊Journal of Agricultural and Food Chemistry
55
發行號23
DOIs
出版狀態Published - 2007 十一月 14

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 農業與生物科學 (全部)

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