Isolation of tumor cells using a new microfluidic incubator with moving-wall structures

Ying Hsin Chuang, Lien Yu Hung, Keng-Fu Hsu, Cheng-Yang Chou, Gwo Bin Lee

研究成果: Conference contribution

摘要

Isolation and detection of tumor cells (TCs) from a large amount of biological samples have been a major challenge in clinical diagnosis. To tackle this problem, a three-dimensional micro incubator using deflecting membranes has been reported by our group previously. However, it requires a relatively complicated fabrication process, which involves bonding of multiple polydimethyl siloxane (PDMS) layers. In this study, a new micro incubator equipped with moving-wall structures is presented. Compared with our previous work, the new chip requires a simpler fabrication process and can be activated with ease. Experimental results showed that the developed micro incubator can be used for isolation of tumor cells when incorporated with magnetic beads. Furthermore, counting and detection of these cancer cells can be further performed when integrated with a micro flow cytometer and a micro nucleic acid module. Therefore, the developed device may be promising for further biomedical applications.

原文English
主出版物標題2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
頁面1931-1934
頁數4
DOIs
出版狀態Published - 2011
事件2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China
持續時間: 2011 六月 52011 六月 9

Other

Other2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
國家China
城市Beijing
期間11-06-0511-06-09

    指紋

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering

引用此

Chuang, Y. H., Hung, L. Y., Hsu, K-F., Chou, C-Y., & Lee, G. B. (2011). Isolation of tumor cells using a new microfluidic incubator with moving-wall structures. 於 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 (頁 1931-1934). [5969373] https://doi.org/10.1109/TRANSDUCERS.2011.5969373