Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the HIV infection epidemic: Incidence and risk factors

Chia Jui Yang, Nan Yao Lee, Yu Hui Lin, Hsin Chun Lee, Wen Chien Ko, Chun Hsing Liao, Cheng Hsin Wu, Chia Ying Hsieh, Pei Ying Wu, Wen Chun Liu, Ya Chu Chang, Chien Ching Hung

研究成果: Article同行評審

34 引文 斯高帕斯(Scopus)

摘要

The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected and 115 HIV-uninfected patients with syphilis who received penicillin treatment. The overall rate of JH reaction was 31.5% (34.6% in HIV-infected patients and 25.2% in HIV-uninfected patients). In multivariate analysis, risk factors for JH reaction included high rapid plasma reagin (RPR) titers (per log2 RPR increase, risk ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early syphilis (RR, 8.59; 95% CI, 4.75-15.56), and prior penicillin treatment (RR, 0.39; 95% CI, 0.20-0.78).

原文English
頁(從 - 到)976-979
頁數4
期刊Clinical Infectious Diseases
51
發行號8
DOIs
出版狀態Published - 2010 十月 15

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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