Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the HIV infection epidemic: Incidence and risk factors

Chia Jui Yang; Nan Yao Lee; Yu Hui Lin; Hsin Chun Lee; Wen Chien Ko; Chun Hsing Liao; Cheng Hsin Wu; Chia Ying Hsieh; Pei Ying Wu; Wen Chun Liu; Ya Chu Chang; Chien Ching Hung

doi:10.1086/656419

Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the HIV infection epidemic: Incidence and risk factors

Chia Jui Yang, Nan Yao Lee, Yu Hui Lin, Hsin Chun Lee, Wen Chien Ko, Chun Hsing Liao, Cheng Hsin Wu, Chia Ying Hsieh, Pei Ying Wu, Wen Chun Liu, Ya Chu Chang, Chien Ching Hung

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61 引文斯高帕斯（Scopus）

摘要

The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected and 115 HIV-uninfected patients with syphilis who received penicillin treatment. The overall rate of JH reaction was 31.5% (34.6% in HIV-infected patients and 25.2% in HIV-uninfected patients). In multivariate analysis, risk factors for JH reaction included high rapid plasma reagin (RPR) titers (per log₂ RPR increase, risk ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early syphilis (RR, 8.59; 95% CI, 4.75-15.56), and prior penicillin treatment (RR, 0.39; 95% CI, 0.20-0.78).

原文	English
頁（從 - 到）	976-979
頁數	4
期刊	Clinical Infectious Diseases
卷	51
發行號	8
DOIs	https://doi.org/10.1086/656419
出版狀態	Published - 2010 10月 15

All Science Journal Classification (ASJC) codes

微生物學（醫學）
傳染性疾病

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10.1086/656419

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Yang, C. J., Lee, N. Y., Lin, Y. H., Lee, H. C., Ko, W. C., Liao, C. H., Wu, C. H., Hsieh, C. Y., Wu, P. Y., Liu, W. C., Chang, Y. C., & Hung, C. C. (2010). Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the HIV infection epidemic: Incidence and risk factors. Clinical Infectious Diseases, 51(8), 976-979. https://doi.org/10.1086/656419

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title = "Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the HIV infection epidemic: Incidence and risk factors",

abstract = "The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected and 115 HIV-uninfected patients with syphilis who received penicillin treatment. The overall rate of JH reaction was 31.5% (34.6% in HIV-infected patients and 25.2% in HIV-uninfected patients). In multivariate analysis, risk factors for JH reaction included high rapid plasma reagin (RPR) titers (per log2 RPR increase, risk ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early syphilis (RR, 8.59; 95% CI, 4.75-15.56), and prior penicillin treatment (RR, 0.39; 95% CI, 0.20-0.78).",

author = "Yang, {Chia Jui} and Lee, {Nan Yao} and Lin, {Yu Hui} and Lee, {Hsin Chun} and Ko, {Wen Chien} and Liao, {Chun Hsing} and Wu, {Cheng Hsin} and Hsieh, {Chia Ying} and Wu, {Pei Ying} and Liu, {Wen Chun} and Chang, {Ya Chu} and Hung, {Chien Ching}",

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AU - Yang, Chia Jui

AU - Lee, Nan Yao

AU - Lin, Yu Hui

AU - Lee, Hsin Chun

AU - Ko, Wen Chien

AU - Liao, Chun Hsing

AU - Wu, Cheng Hsin

AU - Hsieh, Chia Ying

AU - Wu, Pei Ying

AU - Liu, Wen Chun

AU - Chang, Ya Chu

AU - Hung, Chien Ching

PY - 2010/10/15

Y1 - 2010/10/15

N2 - The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected and 115 HIV-uninfected patients with syphilis who received penicillin treatment. The overall rate of JH reaction was 31.5% (34.6% in HIV-infected patients and 25.2% in HIV-uninfected patients). In multivariate analysis, risk factors for JH reaction included high rapid plasma reagin (RPR) titers (per log2 RPR increase, risk ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early syphilis (RR, 8.59; 95% CI, 4.75-15.56), and prior penicillin treatment (RR, 0.39; 95% CI, 0.20-0.78).

AB - The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected and 115 HIV-uninfected patients with syphilis who received penicillin treatment. The overall rate of JH reaction was 31.5% (34.6% in HIV-infected patients and 25.2% in HIV-uninfected patients). In multivariate analysis, risk factors for JH reaction included high rapid plasma reagin (RPR) titers (per log2 RPR increase, risk ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early syphilis (RR, 8.59; 95% CI, 4.75-15.56), and prior penicillin treatment (RR, 0.39; 95% CI, 0.20-0.78).

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Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the HIV infection epidemic: Incidence and risk factors

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