Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis

Pei Lin Wu; Yu Lin Hsu; Tian Shung Wu; K. F. Bastow; Kuo Hsiung Lee

doi:10.1021/ol061873m

Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis

Pei Lin Wu, Yu Lin Hsu, Tian Shung Wu, K. F. Bastow, Kuo Hsiung Lee

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49 引文斯高帕斯（Scopus）

摘要

Three new compounds, kalanchosides A-C (1-3), as well as five known compounds, were isolated from the aerial parts of Kalanchoe gracilis. The compound structures were determined by spectroscopic methods. All eight isolated compounds showed significant cytotoxic activity against a panel of human tumor cell lines, with potency reaching the nanomolar range. However, only bryophyllin B (8) inhibited HIV replication in H9 lymphocyte cells.

原文	English
頁（從 - 到）	5207-5210
頁數	4
期刊	Organic Letters
卷	8
發行號	23
DOIs	https://doi.org/10.1021/ol061873m
出版狀態	Published - 2006 11月 9

All Science Journal Classification (ASJC) codes

生物化學
物理與理論化學
有機化學

UN SDG

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10.1021/ol061873m

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abstract = "Three new compounds, kalanchosides A-C (1-3), as well as five known compounds, were isolated from the aerial parts of Kalanchoe gracilis. The compound structures were determined by spectroscopic methods. All eight isolated compounds showed significant cytotoxic activity against a panel of human tumor cell lines, with potency reaching the nanomolar range. However, only bryophyllin B (8) inhibited HIV replication in H9 lymphocyte cells.",

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AU - Bastow, K. F.

AU - Lee, Kuo Hsiung

PY - 2006/11/9

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N2 - Three new compounds, kalanchosides A-C (1-3), as well as five known compounds, were isolated from the aerial parts of Kalanchoe gracilis. The compound structures were determined by spectroscopic methods. All eight isolated compounds showed significant cytotoxic activity against a panel of human tumor cell lines, with potency reaching the nanomolar range. However, only bryophyllin B (8) inhibited HIV replication in H9 lymphocyte cells.

AB - Three new compounds, kalanchosides A-C (1-3), as well as five known compounds, were isolated from the aerial parts of Kalanchoe gracilis. The compound structures were determined by spectroscopic methods. All eight isolated compounds showed significant cytotoxic activity against a panel of human tumor cell lines, with potency reaching the nanomolar range. However, only bryophyllin B (8) inhibited HIV replication in H9 lymphocyte cells.

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Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis

摘要

All Science Journal Classification (ASJC) codes

UN SDG

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