Ketamine suppresses synchronized discharges in the disinhibited amygdala slice

Gean Po-Wu, Chang Fang-Chia

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

The effect of ketamine on the paroxysmal depolarizing shift (PDS) induced by bicuculline was studied in rat amygdala slices using intracellular recording techniques. Stimulation of the ventral endopyriform nucleus evoked an excitatory postsynaptic potential (EPSP). After exposure to bicuculline (20 μM), the same stimulus intensity evoked burst firing. Superfusion of ketamine reversibly reduced the duration of PDS. Pretreatment of amygdala slices with DL-2-amino-5-phosphonovaleate (DL-APV, 50 μM) occluded the effect of ketamine suggesting that ketamine shortened the burst duration via its blocking action on the NMDA receptors. In all neurons tested, a large depolarizing shift remained in the presence of ketamine. The ketamine-resistant component was blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 8 μM) indicating its mediation by the non-NMDA receptors.

原文English
頁(從 - 到)923-927
頁數5
期刊Brain Research Bulletin
26
發行號6
DOIs
出版狀態Published - 1991 六月

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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