Kinetic modeling of oxidation of antibacterial agents by manganese oxide

Huichun Zhang, Wan Ru Chen, Ching Hua Huang

研究成果: Article同行評審

165 引文 斯高帕斯(Scopus)

摘要

Several groups of popular antibacterial agents (i.e., phenols, fluoroquinolones, aromatic N-oxides, and tetracyclines) were demonstrated in earlier studies to be highly susceptible to oxidation by manganese oxides, a common oxidant in soils. However, because of the high complexity, the reaction kinetics were not fully characterized. A mechanism-based kinetic model has now been developed to successfully describe the entire range of kinetic data for a total of 21 compounds of varying structural characteristics (with R2 > 0.93). The model characterizes the reaction kinetics by two independent parameters, the reaction rate constant (k) and total reactive surface sites (Srxn). The model fitting indicates that the reaction kinetics of antibacterials with MnO2 are controlled by either the rate of surface precursor complex formation (for tetracyclines) or by the rate of electron transfer within the precursor complex (for phenols, fluoroquinolones, and aromatic N-oxides). The effect of reactant concentration, pH, and cosolutes on the reaction kinetics was evaluated and correlated to k and Srxn. All the trends are consistent with the proposed rate-limiting steps. This new model improves the ability to quantitatively evaluate the kinetics of oxidative transformation of organic contaminants by manganese oxides in well-defined systems.

原文English
頁(從 - 到)5548-5554
頁數7
期刊Environmental Science and Technology
42
發行號15
DOIs
出版狀態Published - 2008 8月 1

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 環境化學

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