TY - JOUR
T1 - Lab-on-paper devices for diagnosis of human diseases using urine samples—a review
AU - Tai, Wei Chun
AU - Chang, Yu Chi
AU - Chou, Dean
AU - Fu, Lung Ming
N1 - Funding Information:
Funding: The authors would like to thank the Ministry of Science and Technology of Taiwan for the financial support of this study under Grant Nos. MOST 106-2314-B-006-085-MY3, MOST 106-2221-E-006-253-MY3, MOST 108-2622-E -006-026-CC, and MOST 109-2221-E-006 -043 -MY3.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/8
Y1 - 2021/8
N2 - In recent years, microfluidic lab-on-paper devices have emerged as a rapid and low-cost alternative to traditional laboratory tests. Additionally, they were widely considered as a promising solution for point-of-care testing (POCT) at home or regions that lack medical infrastructure and resources. This review describes important advances in microfluidic lab-on-paper diagnostics for human health monitoring and disease diagnosis over the past five years. The review commenced by explaining the choice of paper, fabrication methods, and detection techniques to realize microfluidic lab-on-paper devices. Then, the sample pretreatment procedure used to improve the detection performance of lab-on-paper devices was introduced. Furthermore, an in-depth review of lab-on-paper devices for disease measurement based on an analysis of urine samples was presented. The review concludes with the potential challenges that the future development of commercial microfluidic lab-on-paper platforms for human disease detection would face.
AB - In recent years, microfluidic lab-on-paper devices have emerged as a rapid and low-cost alternative to traditional laboratory tests. Additionally, they were widely considered as a promising solution for point-of-care testing (POCT) at home or regions that lack medical infrastructure and resources. This review describes important advances in microfluidic lab-on-paper diagnostics for human health monitoring and disease diagnosis over the past five years. The review commenced by explaining the choice of paper, fabrication methods, and detection techniques to realize microfluidic lab-on-paper devices. Then, the sample pretreatment procedure used to improve the detection performance of lab-on-paper devices was introduced. Furthermore, an in-depth review of lab-on-paper devices for disease measurement based on an analysis of urine samples was presented. The review concludes with the potential challenges that the future development of commercial microfluidic lab-on-paper platforms for human disease detection would face.
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U2 - 10.3390/bios11080260
DO - 10.3390/bios11080260
M3 - Review article
C2 - 34436062
AN - SCOPUS:85112785178
VL - 11
JO - Biosensors
JF - Biosensors
SN - 2079-6374
IS - 8
M1 - 260
ER -