Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

Chin Lin Hsien; Mei Hwei Tseng; Ryh Nan Pan; Jang Yang Chang; Ching Chuan Kuo; Tzong Huei Lee; Yueh Hsiung Kuo

doi:10.1016/j.tetlet.2010.11.101

Labdanecaryophyllic acid, a novel cytotoxic C₃₅ terpenoid from Calocedrus macrolepis var. formosana

Chin Lin Hsien, Mei Hwei Tseng, Ryh Nan Pan, Jang Yang Chang, Ching Chuan Kuo, Tzong Huei Lee, Yueh Hsiung Kuo

研究成果: Article

3 引文斯高帕斯（Scopus）

摘要

Chemical investigation of the bark of Calocedrus macrolepis var. formosana, an endemic tree in Taiwan, has led to the isolation of a novel terpenoid 1. Compound 1 with a rare C₃₅ skeleton constructed by a diterpene and a sesquiterpene moieties. Its structure was elucidated by spectroscopic interpretations. The anti-proliferation activity of 1 against human oral epidermoid carcinoma KB cells was evaluated, and the IC₅₀ value was determined to be 9.2 ± 0.4 μM.

原文	English
頁（從 - 到）	515-517
頁數	3
期刊	Tetrahedron Letters
卷	52
發行號	4
DOIs	https://doi.org/10.1016/j.tetlet.2010.11.101
出版狀態	Published - 2011 一月 26

指紋

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

引用此

Hsien, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Lee, T. H., & Kuo, Y. H. (2011). Labdanecaryophyllic acid, a novel cytotoxic C₃₅ terpenoid from Calocedrus macrolepis var. formosana. Tetrahedron Letters, 52(4), 515-517. https://doi.org/10.1016/j.tetlet.2010.11.101

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AU - Chang, Jang Yang

AU - Kuo, Ching Chuan

AU - Lee, Tzong Huei

AU - Kuo, Yueh Hsiung

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存取文件

10.1016/j.tetlet.2010.11.101