Lack of evidence of association of p21(WAF1/CIP1) polymorphism with lung cancer susceptibility and prognosis in Taiwan

Chuen Ming Shih, Pey Tzy Lin, Hui Chun Wang, Wei Chi Huang, Yi Ching Wang

研究成果: Article同行評審

43 引文 斯高帕斯(Scopus)

摘要

An association between the Arg allele of the p21(WAF1/CIP1) codon 31 polymorphism and lung cancer has been reported. However, the genotype distribution of the p21 codon 31 polymorphism, as well as the association of this polymorphism with lung cancer risk and prognosis, remain undefined in the Taiwanese population. Therefore, we investigated the genotype distribution of the p21 codon 31 polymorphism in 155 lung cancer patients and 189 non-cancer controls. The genotype frequencies in the Taiwanese non-cancer controls were 0.51 (Ser) and 0.49 (Arg). χ2 analysis indicated significant differences in Taiwanese genotype distribution of p21 from those reported for Swedes (P = 0.001), Caucasians (P = 0.001), Indians (P = 0.001), and African-Americans (P = 0.001). However, our data did not demonstrate an association of the Arg allele of the p21 polymorphism with lung cancer risk in Taiwan. Lung cancer patients with Ser/Arg and Arg/Arg genotypes were at a nonsignificant 1.15-fold increased risk of lung cancer when compared to individuals with the Ser/Ser genotype (95% CI, 0.70-1.86). In addition, although p21 is a downstream target of p53, we found no significant correlation of the p21 polymorphism with the p53 polymorphism and p53 gene mutation in lung cancer patients. We further investigated the association of the p21 polymorphism with prognosis in 154 lung cancer patients. Patients with the Ser/Ser genotype tended to have a poorer prognosis than those with the Ser/Arg and Arg/Arg genotypes (P = 0.097, by the log rank test). Our data suggest that the p21 codon 31 polymorphism may not play a significant role in cancer susceptibility and the prognosis of lung cancer patients in Taiwan.

原文English
頁(從 - 到)9-15
頁數7
期刊Japanese Journal of Cancer Research
91
發行號1
DOIs
出版狀態Published - 2000 一月

All Science Journal Classification (ASJC) codes

  • 腫瘤科
  • 癌症研究

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