LAMP-Based Point-of-Care Biosensors for Rapid Pathogen Detection

Dhrubajyoti Das, Cheng Wen Lin, Han Sheng Chuang

研究成果: Review article同行評審

17 引文 斯高帕斯(Scopus)


Seeking optimized infectious pathogen detection tools is of primary importance to lessen the spread of infections, allowing prompt medical attention for the infected. Among nucleic-acid-based sensing techniques, loop-mediated isothermal amplification is a promising method, as it provides rapid, sensitive, and specific detection of microbial and viral pathogens and has enormous potential to transform current point-of-care molecular diagnostics. In this review, the advances in LAMP-based point-of-care diagnostics assays developed during the past few years for rapid and sensitive detection of infectious pathogens are outlined. The numerous detection methods of LAMP-based biosensors are discussed in an end-point and real-time manner with ideal examples. We also summarize the trends in LAMP-on-a-chip modalities, such as classical microfluidic, paper-based, and digital LAMP, with their merits and limitations. Finally, we provide our opinion on the future improvement of on-chip LAMP methods. This review serves as an overview of recent breakthroughs in the LAMP approach and their potential for use in the diagnosis of existing and emerging diseases.

出版狀態Published - 2022 12月

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 生物技術
  • 生物醫學工程
  • 儀器
  • 工程(雜項)
  • 臨床生物化學


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