Lateral Inhibition by a Peptide Hormone-Receptor Cascade during Arabidopsis Lateral Root Founder Cell Formation

Koichi Toyokura, Tatsuaki Goh, Hidefumi Shinohara, Akinori Shinoda, Yuki Kondo, Yoshie Okamoto, Takeo Uehara, Koichi Fujimoto, Yoko Okushima, Yoshifumi Ikeyama, Keiji Nakajima, Tetsuro Mimura, Masao Tasaka, Yoshikatsu Matsubayashi, Hidehiro Fukaki

研究成果: Article同行評審

38 引文 斯高帕斯(Scopus)

摘要

In plants, the position of lateral roots (LRs) depends on initiation sites induced by auxin. The domain of high auxin response responsible for LR initiation stretches over several cells, but only a pair of pericycle cells (LR founder cells) will develop into LRs. In this work, we identified a signaling cascade controlling LR formation through lateral inhibition. It comprises a peptide hormone TARGET OF LBD SIXTEEN 2 (TOLS2), its receptor RLK7, and a downstream transcription factor PUCHI. TOLS2 is expressed at the LR founder cells and inhibits LR initiation. Time-lapse imaging of auxin-responsive DR5:LUCIFERASE reporter expression revealed that occasionally two pairs of LR founder cells are specified in close proximity even in wild-type and that one of them exists only transiently and disappears in an RLK7-dependent manner. We propose that the selection of LR founder cells by the peptide hormone-receptor cascade ensures proper LR spacing.

原文English
頁(從 - 到)64-75.e5
期刊Developmental Cell
48
發行號1
DOIs
出版狀態Published - 2019 1月 7

All Science Journal Classification (ASJC) codes

  • 分子生物學
  • 生物化學、遺傳與分子生物學 (全部)
  • 發展生物學
  • 細胞生物學

指紋

深入研究「Lateral Inhibition by a Peptide Hormone-Receptor Cascade during Arabidopsis Lateral Root Founder Cell Formation」主題。共同形成了獨特的指紋。

引用此