Less severe but prolonged course of acute hepatitis a in Human Immunodeficiency Virus (HIV)-infected patients compared with HIV-uninfected patients during an outbreak: A multicenter observational study

Yu Lin Lee, Guan Jhou Chen, Nan Yu Chen, Bo Huang Liou, Ning Chi Wang, Yuan Ti Lee, Chia Jui Yang, Yu Shan Huang, Hung Jen Tang, Shie Shian Huang, Yi Chun Lin, Chien Yu Cheng, Chen Hsiang Lee, Tun Chieh Chen, Ting Shu Wu, Chun Eng Liu, Po Liang Lu, Chien Ching Hung, Yi Chieh Lee, Chien Yu ChengShu Hsing Cheng, Yu Shan Huang, Yuan Ti Lee, Chia Chun Lin, Shih Ping Lin, Chia Yin Hsieh, Hsiu Wen Wang, Mao Wang Ho, Chung Eng Liu, Yu Lin Lee, Yi Chien Lee, Hung Jen Tang, Huei Chun Ku, Chia Wen Li, Nan Yao Lee, Wen Chien Ko, Po Liang Lu, Yen Hsu Chen, Hsi Hsun Lin, Wen Chi Huang, Chen Hsiang Lee, Tun Chieh Che

研究成果: Article

5 引文 (Scopus)

摘要

Background This multicenter retrospective cohort study aimed to compare the clinical presentations and evolution of acute hepatitis A (AHA) between human immunodeficiency virus (HIV)-infected patients and HIV-uninfected counterparts during the AHA outbreak. Methods Clinical and laboratory data were collected from the medical records of the patients with AHA at the 14 hospitals around Taiwan between May 2015 and May 2017. Results A total of 297 adult patients with AHA were included during the study period. Their mean age was 31.4 years (range, 19.0-76.1 years); 93.4% were men and 58.6% were men who have sex with men. Of 265 patients with known HIV serostatus, 166 (62.6%) were HIV infected. Compared with HIV-uninfected patients, HIV-infected patients had a lower peak alanine aminotransferase (ALT) level (median, 1312 vs 2014 IU/L, P =.003), less coagulopathy (6.0% vs 16.2%, P =.007), and less hepatomegaly or splenomegaly on imaging studies, but a higher rate of delayed resolution of hepatitis (38.8% vs 21.3%, P =.009). HIV-infected patients with plasma RNA load <1000 copies/mL while receiving combination antiretroviral therapy (cART) had a higher peak ALT level (median, 1420 vs 978 IU/L, P =.006) and less delay in resolution of hepatitis (30.6% vs 48.8%, P =.047) than patients without cART or with plasma RNA load ≥1000 copies/mL. Conclusions During an AHA outbreak, HIV-infected patients had a lower severity, but delayed resolution, of AHA than HIV-uninfected patients. Better viral suppression by cART alleviated the impact of HIV infection on the disease course of AHA in HIV-infected patients.

原文English
頁(從 - 到)1595-1602
頁數8
期刊Clinical Infectious Diseases
67
發行號10
DOIs
出版狀態Published - 2018 十月 30

指紋

Hepatitis
Multicenter Studies
Observational Studies
Disease Outbreaks
Hepatitis A
HIV
Alanine Transaminase
RNA
Hepatomegaly
Splenomegaly
Acute Disease
Virus Diseases
Taiwan
Medical Records
Cohort Studies
Therapeutics
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

引用此文

Lee, Yu Lin ; Chen, Guan Jhou ; Chen, Nan Yu ; Liou, Bo Huang ; Wang, Ning Chi ; Lee, Yuan Ti ; Yang, Chia Jui ; Huang, Yu Shan ; Tang, Hung Jen ; Huang, Shie Shian ; Lin, Yi Chun ; Cheng, Chien Yu ; Lee, Chen Hsiang ; Chen, Tun Chieh ; Wu, Ting Shu ; Liu, Chun Eng ; Lu, Po Liang ; Hung, Chien Ching ; Lee, Yi Chieh ; Cheng, Chien Yu ; Cheng, Shu Hsing ; Huang, Yu Shan ; Lee, Yuan Ti ; Lin, Chia Chun ; Lin, Shih Ping ; Hsieh, Chia Yin ; Wang, Hsiu Wen ; Ho, Mao Wang ; Liu, Chung Eng ; Lee, Yu Lin ; Lee, Yi Chien ; Tang, Hung Jen ; Ku, Huei Chun ; Li, Chia Wen ; Lee, Nan Yao ; Ko, Wen Chien ; Lu, Po Liang ; Chen, Yen Hsu ; Lin, Hsi Hsun ; Huang, Wen Chi ; Lee, Chen Hsiang ; Che, Tun Chieh. / Less severe but prolonged course of acute hepatitis a in Human Immunodeficiency Virus (HIV)-infected patients compared with HIV-uninfected patients during an outbreak : A multicenter observational study. 於: Clinical Infectious Diseases. 2018 ; 卷 67, 編號 10. 頁 1595-1602.
@article{ba7ba28d6efe4311bc11e765c07ba97d,
title = "Less severe but prolonged course of acute hepatitis a in Human Immunodeficiency Virus (HIV)-infected patients compared with HIV-uninfected patients during an outbreak: A multicenter observational study",
abstract = "Background This multicenter retrospective cohort study aimed to compare the clinical presentations and evolution of acute hepatitis A (AHA) between human immunodeficiency virus (HIV)-infected patients and HIV-uninfected counterparts during the AHA outbreak. Methods Clinical and laboratory data were collected from the medical records of the patients with AHA at the 14 hospitals around Taiwan between May 2015 and May 2017. Results A total of 297 adult patients with AHA were included during the study period. Their mean age was 31.4 years (range, 19.0-76.1 years); 93.4{\%} were men and 58.6{\%} were men who have sex with men. Of 265 patients with known HIV serostatus, 166 (62.6{\%}) were HIV infected. Compared with HIV-uninfected patients, HIV-infected patients had a lower peak alanine aminotransferase (ALT) level (median, 1312 vs 2014 IU/L, P =.003), less coagulopathy (6.0{\%} vs 16.2{\%}, P =.007), and less hepatomegaly or splenomegaly on imaging studies, but a higher rate of delayed resolution of hepatitis (38.8{\%} vs 21.3{\%}, P =.009). HIV-infected patients with plasma RNA load <1000 copies/mL while receiving combination antiretroviral therapy (cART) had a higher peak ALT level (median, 1420 vs 978 IU/L, P =.006) and less delay in resolution of hepatitis (30.6{\%} vs 48.8{\%}, P =.047) than patients without cART or with plasma RNA load ≥1000 copies/mL. Conclusions During an AHA outbreak, HIV-infected patients had a lower severity, but delayed resolution, of AHA than HIV-uninfected patients. Better viral suppression by cART alleviated the impact of HIV infection on the disease course of AHA in HIV-infected patients.",
author = "Lee, {Yu Lin} and Chen, {Guan Jhou} and Chen, {Nan Yu} and Liou, {Bo Huang} and Wang, {Ning Chi} and Lee, {Yuan Ti} and Yang, {Chia Jui} and Huang, {Yu Shan} and Tang, {Hung Jen} and Huang, {Shie Shian} and Lin, {Yi Chun} and Cheng, {Chien Yu} and Lee, {Chen Hsiang} and Chen, {Tun Chieh} and Wu, {Ting Shu} and Liu, {Chun Eng} and Lu, {Po Liang} and Hung, {Chien Ching} and Lee, {Yi Chieh} and Cheng, {Chien Yu} and Cheng, {Shu Hsing} and Huang, {Yu Shan} and Lee, {Yuan Ti} and Lin, {Chia Chun} and Lin, {Shih Ping} and Hsieh, {Chia Yin} and Wang, {Hsiu Wen} and Ho, {Mao Wang} and Liu, {Chung Eng} and Lee, {Yu Lin} and Lee, {Yi Chien} and Tang, {Hung Jen} and Ku, {Huei Chun} and Li, {Chia Wen} and Lee, {Nan Yao} and Ko, {Wen Chien} and Lu, {Po Liang} and Chen, {Yen Hsu} and Lin, {Hsi Hsun} and Huang, {Wen Chi} and Lee, {Chen Hsiang} and Che, {Tun Chieh}",
year = "2018",
month = "10",
day = "30",
doi = "10.1093/cid/ciy328",
language = "English",
volume = "67",
pages = "1595--1602",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "10",

}

Lee, YL, Chen, GJ, Chen, NY, Liou, BH, Wang, NC, Lee, YT, Yang, CJ, Huang, YS, Tang, HJ, Huang, SS, Lin, YC, Cheng, CY, Lee, CH, Chen, TC, Wu, TS, Liu, CE, Lu, PL, Hung, CC, Lee, YC, Cheng, CY, Cheng, SH, Huang, YS, Lee, YT, Lin, CC, Lin, SP, Hsieh, CY, Wang, HW, Ho, MW, Liu, CE, Lee, YL, Lee, YC, Tang, HJ, Ku, HC, Li, CW, Lee, NY, Ko, WC, Lu, PL, Chen, YH, Lin, HH, Huang, WC, Lee, CH & Che, TC 2018, 'Less severe but prolonged course of acute hepatitis a in Human Immunodeficiency Virus (HIV)-infected patients compared with HIV-uninfected patients during an outbreak: A multicenter observational study', Clinical Infectious Diseases, 卷 67, 編號 10, 頁 1595-1602. https://doi.org/10.1093/cid/ciy328

Less severe but prolonged course of acute hepatitis a in Human Immunodeficiency Virus (HIV)-infected patients compared with HIV-uninfected patients during an outbreak : A multicenter observational study. / Lee, Yu Lin; Chen, Guan Jhou; Chen, Nan Yu; Liou, Bo Huang; Wang, Ning Chi; Lee, Yuan Ti; Yang, Chia Jui; Huang, Yu Shan; Tang, Hung Jen; Huang, Shie Shian; Lin, Yi Chun; Cheng, Chien Yu; Lee, Chen Hsiang; Chen, Tun Chieh; Wu, Ting Shu; Liu, Chun Eng; Lu, Po Liang; Hung, Chien Ching; Lee, Yi Chieh; Cheng, Chien Yu; Cheng, Shu Hsing; Huang, Yu Shan; Lee, Yuan Ti; Lin, Chia Chun; Lin, Shih Ping; Hsieh, Chia Yin; Wang, Hsiu Wen; Ho, Mao Wang; Liu, Chung Eng; Lee, Yu Lin; Lee, Yi Chien; Tang, Hung Jen; Ku, Huei Chun; Li, Chia Wen; Lee, Nan Yao; Ko, Wen Chien; Lu, Po Liang; Chen, Yen Hsu; Lin, Hsi Hsun; Huang, Wen Chi; Lee, Chen Hsiang; Che, Tun Chieh.

於: Clinical Infectious Diseases, 卷 67, 編號 10, 30.10.2018, p. 1595-1602.

研究成果: Article

TY - JOUR

T1 - Less severe but prolonged course of acute hepatitis a in Human Immunodeficiency Virus (HIV)-infected patients compared with HIV-uninfected patients during an outbreak

T2 - A multicenter observational study

AU - Lee, Yu Lin

AU - Chen, Guan Jhou

AU - Chen, Nan Yu

AU - Liou, Bo Huang

AU - Wang, Ning Chi

AU - Lee, Yuan Ti

AU - Yang, Chia Jui

AU - Huang, Yu Shan

AU - Tang, Hung Jen

AU - Huang, Shie Shian

AU - Lin, Yi Chun

AU - Cheng, Chien Yu

AU - Lee, Chen Hsiang

AU - Chen, Tun Chieh

AU - Wu, Ting Shu

AU - Liu, Chun Eng

AU - Lu, Po Liang

AU - Hung, Chien Ching

AU - Lee, Yi Chieh

AU - Cheng, Chien Yu

AU - Cheng, Shu Hsing

AU - Huang, Yu Shan

AU - Lee, Yuan Ti

AU - Lin, Chia Chun

AU - Lin, Shih Ping

AU - Hsieh, Chia Yin

AU - Wang, Hsiu Wen

AU - Ho, Mao Wang

AU - Liu, Chung Eng

AU - Lee, Yu Lin

AU - Lee, Yi Chien

AU - Tang, Hung Jen

AU - Ku, Huei Chun

AU - Li, Chia Wen

AU - Lee, Nan Yao

AU - Ko, Wen Chien

AU - Lu, Po Liang

AU - Chen, Yen Hsu

AU - Lin, Hsi Hsun

AU - Huang, Wen Chi

AU - Lee, Chen Hsiang

AU - Che, Tun Chieh

PY - 2018/10/30

Y1 - 2018/10/30

N2 - Background This multicenter retrospective cohort study aimed to compare the clinical presentations and evolution of acute hepatitis A (AHA) between human immunodeficiency virus (HIV)-infected patients and HIV-uninfected counterparts during the AHA outbreak. Methods Clinical and laboratory data were collected from the medical records of the patients with AHA at the 14 hospitals around Taiwan between May 2015 and May 2017. Results A total of 297 adult patients with AHA were included during the study period. Their mean age was 31.4 years (range, 19.0-76.1 years); 93.4% were men and 58.6% were men who have sex with men. Of 265 patients with known HIV serostatus, 166 (62.6%) were HIV infected. Compared with HIV-uninfected patients, HIV-infected patients had a lower peak alanine aminotransferase (ALT) level (median, 1312 vs 2014 IU/L, P =.003), less coagulopathy (6.0% vs 16.2%, P =.007), and less hepatomegaly or splenomegaly on imaging studies, but a higher rate of delayed resolution of hepatitis (38.8% vs 21.3%, P =.009). HIV-infected patients with plasma RNA load <1000 copies/mL while receiving combination antiretroviral therapy (cART) had a higher peak ALT level (median, 1420 vs 978 IU/L, P =.006) and less delay in resolution of hepatitis (30.6% vs 48.8%, P =.047) than patients without cART or with plasma RNA load ≥1000 copies/mL. Conclusions During an AHA outbreak, HIV-infected patients had a lower severity, but delayed resolution, of AHA than HIV-uninfected patients. Better viral suppression by cART alleviated the impact of HIV infection on the disease course of AHA in HIV-infected patients.

AB - Background This multicenter retrospective cohort study aimed to compare the clinical presentations and evolution of acute hepatitis A (AHA) between human immunodeficiency virus (HIV)-infected patients and HIV-uninfected counterparts during the AHA outbreak. Methods Clinical and laboratory data were collected from the medical records of the patients with AHA at the 14 hospitals around Taiwan between May 2015 and May 2017. Results A total of 297 adult patients with AHA were included during the study period. Their mean age was 31.4 years (range, 19.0-76.1 years); 93.4% were men and 58.6% were men who have sex with men. Of 265 patients with known HIV serostatus, 166 (62.6%) were HIV infected. Compared with HIV-uninfected patients, HIV-infected patients had a lower peak alanine aminotransferase (ALT) level (median, 1312 vs 2014 IU/L, P =.003), less coagulopathy (6.0% vs 16.2%, P =.007), and less hepatomegaly or splenomegaly on imaging studies, but a higher rate of delayed resolution of hepatitis (38.8% vs 21.3%, P =.009). HIV-infected patients with plasma RNA load <1000 copies/mL while receiving combination antiretroviral therapy (cART) had a higher peak ALT level (median, 1420 vs 978 IU/L, P =.006) and less delay in resolution of hepatitis (30.6% vs 48.8%, P =.047) than patients without cART or with plasma RNA load ≥1000 copies/mL. Conclusions During an AHA outbreak, HIV-infected patients had a lower severity, but delayed resolution, of AHA than HIV-uninfected patients. Better viral suppression by cART alleviated the impact of HIV infection on the disease course of AHA in HIV-infected patients.

UR - http://www.scopus.com/inward/record.url?scp=85055639085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055639085&partnerID=8YFLogxK

U2 - 10.1093/cid/ciy328

DO - 10.1093/cid/ciy328

M3 - Article

C2 - 29672699

AN - SCOPUS:85055639085

VL - 67

SP - 1595

EP - 1602

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 10

ER -