Less severe but prolonged course of acute hepatitis a in Human Immunodeficiency Virus (HIV)-infected patients compared with HIV-uninfected patients during an outbreak: A multicenter observational study

Yu Lin Lee, Guan Jhou Chen, Nan Yu Chen, Bo Huang Liou, Ning Chi Wang, Yuan Ti Lee, Chia Jui Yang, Yu Shan Huang, Hung Jen Tang, Shie Shian Huang, Yi Chun Lin, Chien Yu Cheng, Chen Hsiang Lee, Tun Chieh Chen, Ting Shu Wu, Chun Eng Liu, Po Liang Lu, Chien Ching Hung, Yi Chieh Lee, Chien Yu ChengShu Hsing Cheng, Yu Shan Huang, Yuan Ti Lee, Chia Chun Lin, Shih Ping Lin, Chia Yin Hsieh, Hsiu Wen Wang, Mao Wang Ho, Chung Eng Liu, Yu Lin Lee, Yi Chien Lee, Hung Jen Tang, Huei Chun Ku, Chia Wen Li, Nan Yao Lee, Wen Chien Ko, Po Liang Lu, Yen Hsu Chen, Hsi Hsun Lin, Wen Chi Huang, Chen Hsiang Lee, Tun Chieh Che

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Background This multicenter retrospective cohort study aimed to compare the clinical presentations and evolution of acute hepatitis A (AHA) between human immunodeficiency virus (HIV)-infected patients and HIV-uninfected counterparts during the AHA outbreak. Methods Clinical and laboratory data were collected from the medical records of the patients with AHA at the 14 hospitals around Taiwan between May 2015 and May 2017. Results A total of 297 adult patients with AHA were included during the study period. Their mean age was 31.4 years (range, 19.0-76.1 years); 93.4% were men and 58.6% were men who have sex with men. Of 265 patients with known HIV serostatus, 166 (62.6%) were HIV infected. Compared with HIV-uninfected patients, HIV-infected patients had a lower peak alanine aminotransferase (ALT) level (median, 1312 vs 2014 IU/L, P =.003), less coagulopathy (6.0% vs 16.2%, P =.007), and less hepatomegaly or splenomegaly on imaging studies, but a higher rate of delayed resolution of hepatitis (38.8% vs 21.3%, P =.009). HIV-infected patients with plasma RNA load <1000 copies/mL while receiving combination antiretroviral therapy (cART) had a higher peak ALT level (median, 1420 vs 978 IU/L, P =.006) and less delay in resolution of hepatitis (30.6% vs 48.8%, P =.047) than patients without cART or with plasma RNA load ≥1000 copies/mL. Conclusions During an AHA outbreak, HIV-infected patients had a lower severity, but delayed resolution, of AHA than HIV-uninfected patients. Better viral suppression by cART alleviated the impact of HIV infection on the disease course of AHA in HIV-infected patients.

原文English
頁(從 - 到)1595-1602
頁數8
期刊Clinical Infectious Diseases
67
發行號10
DOIs
出版狀態Published - 2018 十月 30

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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