Level of transforming growth factor beta 1 is elevated in cerebrospinal fluid of children with acute bacterial meningitis

Chao-Ching Huang, Ying Chao Chang, Nan-Haw Chow, Shan-Tair Wang

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

We investigated the levels of transforming growth factor beta 1 (TGF-β1) in cerebrospinal fluid (CSF) in children with meningitis, with a view to prognostic relevance. CSF TGF-β1 levels on admission were measured by a sandwich enzyme immunoassay in children with bacterial meningitis (n = 16), aseptic meningitis (n = 12), and control subjects without evidence of central nervous system (CNS) infection (n = 16). Patients were followed up for a mean duration of 13 months, and neurodevelopmental sequelae was determined for those with bacterial meningitis. On admission, CSF TGF-β1 levels were significantly higher in children with bacterial meningitis (mean, standard error, 32.92, 2.36 pg/ml) as opposed to those with aseptic meningitis (25.26, 1.72 pg/ml) (P = 0.0155), or control subjects (20.53, 1.05 pg/ml) (P < 0.0001). The CSF TGF-β1 levels in children with aseptic meningitis were higher than those in the control group, but without significance (P = 0.02). No apparent correlation existed between CSF TGF-β1 levels and CSF protein or cell counts in patients with bacterial meningitis. No significant difference in CSF TGF-β1 levels was found between patients with or without major sequelae following bacterial meningitis.

原文English
頁(從 - 到)634-638
頁數5
期刊Journal of Neurology
244
發行號10
DOIs
出版狀態Published - 1997 十一月 24

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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