Light triggering goldsomes enable local NO-generation and alleviate pathological vasoconstriction

I. Ju Lee, Po Tsung Kao, Shao An Hung, Zih Wun Wang, Hui Jen Lin, Wei Tien Chang, Chen Sheng Yeh, Ian Liau

研究成果: Article同行評審

摘要

While nitric oxide (NO) can remedy vasoconstriction, inhalation of NO may cause systematic toxicity. We report a goldsome, which comprises a hollowed poly(lactic-co-glycolic acid) (PLGA) polymersome with S-nitrosoglutathione (GSNO, a NO donor) molecules and gold nanoparticles (Au NPs) incorporated in its hydrophilic core and hydrophobic membrane, respectively. Photothermal heating caused breakdown of polymersomes and enabled NO generation through reaction between GSNO and Au NPs. Photo-illumination at the zebrafish head led to local NO generation and selective cerebral vasodilation while it had little effects in regions away from the illumination site, and effectively mitigated hypoxia induced cerebral vasoconstriction. We demonstrate a translational potential by showing photo-stimulated NO generation with a clinical intravascular optical catheter. In conclusion, the goldsome, which enables light stimulated local NO generation and can be delivered with clinical intravascular optical catheters, should extend applications of NO therapies while surmounting limitations associated with systemic administration.

原文English
文章編號102282
期刊Nanomedicine: Nanotechnology, Biology, and Medicine
30
DOIs
出版狀態Published - 2020 11月

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 醫藥(雜項)
  • 分子醫學
  • 生物醫學工程
  • 材料科學(全部)
  • 藥學科學

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