Local Application of Ultrasound Attenuates Neuropathic Allodynia and Proinflammatory Cytokines in Rats after Thoracotomy

Ching-Hsia Hung, Chong Chi Chiu, Chen Chih Liu, Yu Wen Chen

研究成果: Article

1 引文 (Scopus)

摘要

Background and Objectives We aimed to investigate the effect of therapeutic ultrasound (TU) on pain sensitivity and the concentration inflammatory cytokines in a thoracotomy rat model. Methods Rats were distributed randomly into 4 groups: (1) sham operated, (2) thoracotomy and rib retraction (TRR), (3) TRR rats that received TU (TRR + TU-1), and (4) TRR rats that received TU with the ultrasound turned off (TRR + TU-0). Ultrasound was set at 1-MHz frequency (1.0-W/cm2 intensity and 100% duty cycle for 5 minutes), began on postoperative day (POD) 10, and then continued once per day, 5 days a week for 3 weeks. Results The TRR and TRR + TU-0 rats encountered tactile hypersensitivity from PODs 10 to 28. Mechanical withdrawal thresholds were increased (all P < 0.05) following 5 days of TU, but thresholds remained significantly lower than baseline values. Therapeutic ultrasound increased the subcutaneous, but not body temperature. All groups receiving TRR demonstrated an increase in concentration of interleukin 1β and tumor necrosis factor α (TNF-α) on POD 14; however, the rise in TNF-α concentration was less in the TU-treated group than in the others. The decrease in concentration was greatest in the TRR + TU-1 group and similar between the TRR and TRR + TU-0 groups. Conclusions Mechanical allodynia was partially resolved with TU. Tissue temperature increased with ultrasound, while TU restricted the up-regulation of interleukin 1β and TNF-α around the injured intercostal nerve.

原文English
頁(從 - 到)193-199
頁數7
期刊Regional anesthesia and pain medicine
43
發行號2
DOIs
出版狀態Published - 2018 二月 1

指紋

Hyperalgesia
Thoracotomy
Ribs
Cytokines
Therapeutics
Tumor Necrosis Factor-alpha
Interleukin-1
Intercostal Nerves
Touch
Therapeutic Uses
Body Temperature
Hypersensitivity
Up-Regulation

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

引用此文

@article{865afca56e634ce0b5f213fc7e973538,
title = "Local Application of Ultrasound Attenuates Neuropathic Allodynia and Proinflammatory Cytokines in Rats after Thoracotomy",
abstract = "Background and Objectives We aimed to investigate the effect of therapeutic ultrasound (TU) on pain sensitivity and the concentration inflammatory cytokines in a thoracotomy rat model. Methods Rats were distributed randomly into 4 groups: (1) sham operated, (2) thoracotomy and rib retraction (TRR), (3) TRR rats that received TU (TRR + TU-1), and (4) TRR rats that received TU with the ultrasound turned off (TRR + TU-0). Ultrasound was set at 1-MHz frequency (1.0-W/cm2 intensity and 100{\%} duty cycle for 5 minutes), began on postoperative day (POD) 10, and then continued once per day, 5 days a week for 3 weeks. Results The TRR and TRR + TU-0 rats encountered tactile hypersensitivity from PODs 10 to 28. Mechanical withdrawal thresholds were increased (all P < 0.05) following 5 days of TU, but thresholds remained significantly lower than baseline values. Therapeutic ultrasound increased the subcutaneous, but not body temperature. All groups receiving TRR demonstrated an increase in concentration of interleukin 1β and tumor necrosis factor α (TNF-α) on POD 14; however, the rise in TNF-α concentration was less in the TU-treated group than in the others. The decrease in concentration was greatest in the TRR + TU-1 group and similar between the TRR and TRR + TU-0 groups. Conclusions Mechanical allodynia was partially resolved with TU. Tissue temperature increased with ultrasound, while TU restricted the up-regulation of interleukin 1β and TNF-α around the injured intercostal nerve.",
author = "Ching-Hsia Hung and Chiu, {Chong Chi} and Liu, {Chen Chih} and Chen, {Yu Wen}",
year = "2018",
month = "2",
day = "1",
doi = "10.1097/AAP.0000000000000717",
language = "English",
volume = "43",
pages = "193--199",
journal = "Regional Anesthesia and Pain Medicine",
issn = "1098-7339",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

Local Application of Ultrasound Attenuates Neuropathic Allodynia and Proinflammatory Cytokines in Rats after Thoracotomy. / Hung, Ching-Hsia; Chiu, Chong Chi; Liu, Chen Chih; Chen, Yu Wen.

於: Regional anesthesia and pain medicine, 卷 43, 編號 2, 01.02.2018, p. 193-199.

研究成果: Article

TY - JOUR

T1 - Local Application of Ultrasound Attenuates Neuropathic Allodynia and Proinflammatory Cytokines in Rats after Thoracotomy

AU - Hung, Ching-Hsia

AU - Chiu, Chong Chi

AU - Liu, Chen Chih

AU - Chen, Yu Wen

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background and Objectives We aimed to investigate the effect of therapeutic ultrasound (TU) on pain sensitivity and the concentration inflammatory cytokines in a thoracotomy rat model. Methods Rats were distributed randomly into 4 groups: (1) sham operated, (2) thoracotomy and rib retraction (TRR), (3) TRR rats that received TU (TRR + TU-1), and (4) TRR rats that received TU with the ultrasound turned off (TRR + TU-0). Ultrasound was set at 1-MHz frequency (1.0-W/cm2 intensity and 100% duty cycle for 5 minutes), began on postoperative day (POD) 10, and then continued once per day, 5 days a week for 3 weeks. Results The TRR and TRR + TU-0 rats encountered tactile hypersensitivity from PODs 10 to 28. Mechanical withdrawal thresholds were increased (all P < 0.05) following 5 days of TU, but thresholds remained significantly lower than baseline values. Therapeutic ultrasound increased the subcutaneous, but not body temperature. All groups receiving TRR demonstrated an increase in concentration of interleukin 1β and tumor necrosis factor α (TNF-α) on POD 14; however, the rise in TNF-α concentration was less in the TU-treated group than in the others. The decrease in concentration was greatest in the TRR + TU-1 group and similar between the TRR and TRR + TU-0 groups. Conclusions Mechanical allodynia was partially resolved with TU. Tissue temperature increased with ultrasound, while TU restricted the up-regulation of interleukin 1β and TNF-α around the injured intercostal nerve.

AB - Background and Objectives We aimed to investigate the effect of therapeutic ultrasound (TU) on pain sensitivity and the concentration inflammatory cytokines in a thoracotomy rat model. Methods Rats were distributed randomly into 4 groups: (1) sham operated, (2) thoracotomy and rib retraction (TRR), (3) TRR rats that received TU (TRR + TU-1), and (4) TRR rats that received TU with the ultrasound turned off (TRR + TU-0). Ultrasound was set at 1-MHz frequency (1.0-W/cm2 intensity and 100% duty cycle for 5 minutes), began on postoperative day (POD) 10, and then continued once per day, 5 days a week for 3 weeks. Results The TRR and TRR + TU-0 rats encountered tactile hypersensitivity from PODs 10 to 28. Mechanical withdrawal thresholds were increased (all P < 0.05) following 5 days of TU, but thresholds remained significantly lower than baseline values. Therapeutic ultrasound increased the subcutaneous, but not body temperature. All groups receiving TRR demonstrated an increase in concentration of interleukin 1β and tumor necrosis factor α (TNF-α) on POD 14; however, the rise in TNF-α concentration was less in the TU-treated group than in the others. The decrease in concentration was greatest in the TRR + TU-1 group and similar between the TRR and TRR + TU-0 groups. Conclusions Mechanical allodynia was partially resolved with TU. Tissue temperature increased with ultrasound, while TU restricted the up-regulation of interleukin 1β and TNF-α around the injured intercostal nerve.

UR - http://www.scopus.com/inward/record.url?scp=85041488562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041488562&partnerID=8YFLogxK

U2 - 10.1097/AAP.0000000000000717

DO - 10.1097/AAP.0000000000000717

M3 - Article

C2 - 29278606

AN - SCOPUS:85041488562

VL - 43

SP - 193

EP - 199

JO - Regional Anesthesia and Pain Medicine

JF - Regional Anesthesia and Pain Medicine

SN - 1098-7339

IS - 2

ER -