Localized heating of tumor cells utilizing superparamagnetic nanoparticles

Hao Yu Tseng, Chen Yi Lee, Ying Hsia Shih, Xi-Zhang Lin, Gwo Bin Lee

研究成果: Conference contribution

1 引文 斯高帕斯(Scopus)

摘要

This paper presents an investigation of hyperthermia cancer therapy utilizing high-frequency magnetic field to induce a localized temperature increase on tumors by using superparamagnetic nanoparticles. In-vitro and in-vivo experiments showed the feasibility of hyperthermia cancer therapy. The relationship between temperature rise and cell survival rate was also investigated. While CT-26 colon cancer cells were heated above 45°C, the survival rate of cancer cells would be greatly reduced. A temperature increase as high as 59.5°C can be successfully generated in rat livers. In-vivo tests also indicated that hyperthermia cancer therapy using this approach could significantly suppress the growth rate of tumors by utilizing concentrated magnetic nanoparticles and temperature-sensitive hydrogel, which was used to secure the nanoparticles in the target tumor tissue. Furthermore, a feedback temperature control system was successfully developed to keep the nanoparticles at a constant temperature to prevent overheating in the tumors such that a safer and more precise cancer therapy is feasible. The developed technique may be promising for the hyperthermia cancer therapy.

原文English
主出版物標題2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings
頁面969-974
頁數6
DOIs
出版狀態Published - 2007 十二月 1
事件2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007 - Hong Kong, China
持續時間: 2007 八月 22007 八月 5

出版系列

名字2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings

Other

Other2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007
國家China
城市Hong Kong
期間07-08-0207-08-05

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

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    Tseng, H. Y., Lee, C. Y., Shih, Y. H., Lin, X-Z., & Lee, G. B. (2007). Localized heating of tumor cells utilizing superparamagnetic nanoparticles. 於 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings (頁 969-974). [4601345] (2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings). https://doi.org/10.1109/NANO.2007.4601345