Long-term enhancement of EPSP and NMDA receptor-mediated synaptic transmission in the amygdala

Gean Po-wu, Chang Fang-Chia, Huang Chiung-Chun, Lin Jju-Home, Way Long-Joy

研究成果: Article同行評審

78 引文 斯高帕斯(Scopus)

摘要

An in vitro slice preparation of rat amygdala was used to study the long-term modifications of synaptic efficacy following high-frequency stimulation of the ventral endopyriform nucleus. Delivery of brief tetani to the afferent fibers led to a long-term potentiation (LTP) of the amplitude and the initial slope of excitatory postsynaptic potential (EPSP). Pretreatment the slices with DL-2-amino-5-phosphonovaleate (DL-APV, 50 μM) blocked the induction of LTP, indicating that N-methyl-D-aspartate (NMDA) receptor activation is required for induction. NMDA receptor-mediated component of synaptic response (EPSPNMDA) was isolated by application of a solution containing 6-cyano-7-nitro-quinoxaline-2,3-dione (CNQX. 10 μM) and bicuculline (20 μM). Tetanic stimulation led to a lasting potentiation of the EPSPNMDA. These results suggest that brief repetitive stimulation of afferent pathway produces forms of LTP that share many properties of LTP seen in the CA1 region of the hippocampus.

原文English
頁(從 - 到)7-11
頁數5
期刊Brain Research Bulletin
31
發行號1-2
DOIs
出版狀態Published - 1993

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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