Low miR-10b-3p associated with sorafenib resistance in hepatocellular carcinoma

Yu Yun Shao, Pai Sheng Chen, Liang In Lin, Bin Shyun Lee, Andrew Ling, Ann Lii Cheng, Chiun Hsu, Da Liang Ou

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Background: Sorafenib is one of the standard first-line therapies for advanced hepatocellular carcinoma (HCC). Unfortunately, there are currently no appropriate biomarkers to predict the clinical efficacy of sorafenib in HCC patients. MicroRNAs (miRNAs) have been studied for their biological functions and clinical applications in human cancers. Methods: In this study, we found that miR-10b-3p expression was suppressed in sorafenib-resistant HCC cell lines through miRNA microarray analysis. Results: Sorafenib-induced apoptosis in HCC cells was significantly enhanced by miR-10b-3p overexpression and partially abrogated by miR-10b-3p depletion. Among 45 patients who received sorafenib for advanced HCC, those with high miR-10b-3p levels, compared to those with low levels, exhibited significantly longer overall survival (OS) (median, 13.9 vs. 3.5 months, p = 0.021), suggesting that high serum miR-10b-3p level in patients treated with sorafenib for advanced HCC serves as a biomarker for predicting sorafenib efficacy. Furthermore, we confirmed that cyclin E1, a known promoter of sorafenib resistance reported by our previous study, is the downstream target for miR-10b-3p in HCC cells. Conclusions: This study not only identified the molecular target for miR-10b-3p, but also provided evidence that circulating miR-10b-3p may be used as a biomarker for predicting sorafenib sensitivity in patients with HCC.

原文English
頁(從 - 到)1806-1814
頁數9
期刊British Journal of Cancer
126
發行號12
DOIs
出版狀態Accepted/In press - 2022

All Science Journal Classification (ASJC) codes

  • 腫瘤科
  • 癌症研究

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