Lysine-block-tyrosine block copolypeptides: Self-assembly, cross-linking, and conjugation of targeted ligand for drug encapsulation

Yun Chiao Huang, Yao Sheng Yang, Tzu Yu Lai, Jeng Shiung Jan

研究成果: Article同行評審

34 引文 斯高帕斯(Scopus)

摘要

This report describes the synthesis and self-assembly of poly(L-lysine)-block-poly(L-tyrosine) (PLL-b-PLT) block copolypeptides. These block copolypeptides self-assembled to form vesicles or micelles with sizes between 100 and 350 nm as confirmed by light scattering and electron microscopy. The spectral properties and chain conformation of these block copolypeptides were studied by UV/vis, fluorescence, and circular dichroism. UV cross-linked micelles and vesicles can be prepared by dimerization of tyrosine residues, evidenced by the presence of fluorescence emission at 410e430 nm. The block copolypeptides can be functionalized by a variety of cell-targeted ligands as demonstrated by conjugation of a saccharide group, lactobionolactone, onto the copolymers. A preliminary evaluation of the glycopeptides for in vitro drug release was studied. Due to the unique features exhibited by both PLL and PLT segments, it can be expected that these amphiphilic block copolypeptides to be useful as targeted drug carriers, functional nanobioreactors, and biomimetic encapsulants in the biomedical fields.

原文English
頁(從 - 到)913-922
頁數10
期刊polymer
53
發行號4
DOIs
出版狀態Published - 2012 2月 17

All Science Journal Classification (ASJC) codes

  • 有機化學
  • 聚合物和塑料
  • 材料化學

指紋

深入研究「Lysine-block-tyrosine block copolypeptides: Self-assembly, cross-linking, and conjugation of targeted ligand for drug encapsulation」主題。共同形成了獨特的指紋。

引用此