Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy

Hung Wei Yang; Hao Li Liu; Meng Lin Li; I. Wen Hsi; Chih Tai Fan; Chiung Yin Huang; Yu Jen Lu; Mu Yi Hua; Hsin Yi Chou; Jiunn Woei Liaw; Chen Chi M. Ma; Kuo Chen Wei

doi:10.1016/j.biomaterials.2013.03.085

Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy

Hung Wei Yang
, Hao Li Liu
, Meng Lin Li
, I. Wen Hsi
, Chih Tai Fan
, Chiung Yin Huang
, Yu Jen Lu
, Mu Yi Hua
, Hsin Yi Chou
, Jiunn Woei Liaw
, Chen Chi M. Ma
, Kuo Chen Wei

生物醫學工程學系

研究成果: Article › 同行評審

134 引文斯高帕斯（Scopus）

摘要

Nanomedicine can provide a multi-functional platform for image-guided diagnosis and treatment of cancer. Although gold nanorods (GNRs) have been developed for photoacoustic (PA) imaging and near infra-red (NIR) photothermal applications, their efficiency has remained limited by low thermal stability. Here we present the synthesis, characterization, and functional evaluation of non-cytotoxic magnetic polymer-modified gold nanorods (MPGNRs), designed to act as dual magnetic resonance imaging (MRI) and PA imaging contrast agents. In addition, their high magnetization allowed MPGNRs to be actively localized and concentrated by targeting with an external magnet. Finally, MPGNRs significantly enhanced the NIR-laser-induced photothermal effect due to their increased thermal stability. MPGNRs thus provide a promising new theranostic platform for cancer diagnosis and treatment by combining dual MR/PA imaging with highly effective targeted photothermal therapy.

原文	English
頁（從 - 到）	5651-5660
頁數	10
期刊	Biomaterials
卷	34
發行號	22
DOIs	https://doi.org/10.1016/j.biomaterials.2013.03.085
出版狀態	Published - 2013 7月

All Science Journal Classification (ASJC) codes

生物工程
陶瓷和複合材料
生物物理學
生物材料
材料力學

UN SDG

此研究成果有助於以下永續發展目標

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10.1016/j.biomaterials.2013.03.085

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Yang, H. W., Liu, H. L., Li, M. L., Hsi, I. W., Fan, C. T., Huang, C. Y., Lu, Y. J., Hua, M. Y., Chou, H. Y., Liaw, J. W., Ma, C. C. M., & Wei, K. C. (2013). Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy. Biomaterials, 34(22), 5651-5660. https://doi.org/10.1016/j.biomaterials.2013.03.085

@article{6f74a448a1814a768df043425345ce82,

title = "Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy",

abstract = "Nanomedicine can provide a multi-functional platform for image-guided diagnosis and treatment of cancer. Although gold nanorods (GNRs) have been developed for photoacoustic (PA) imaging and near infra-red (NIR) photothermal applications, their efficiency has remained limited by low thermal stability. Here we present the synthesis, characterization, and functional evaluation of non-cytotoxic magnetic polymer-modified gold nanorods (MPGNRs), designed to act as dual magnetic resonance imaging (MRI) and PA imaging contrast agents. In addition, their high magnetization allowed MPGNRs to be actively localized and concentrated by targeting with an external magnet. Finally, MPGNRs significantly enhanced the NIR-laser-induced photothermal effect due to their increased thermal stability. MPGNRs thus provide a promising new theranostic platform for cancer diagnosis and treatment by combining dual MR/PA imaging with highly effective targeted photothermal therapy.",

author = "Yang, \{Hung Wei\} and Liu, \{Hao Li\} and Li, \{Meng Lin\} and Hsi, \{I. Wen\} and Fan, \{Chih Tai\} and Huang, \{Chiung Yin\} and Lu, \{Yu Jen\} and Hua, \{Mu Yi\} and Chou, \{Hsin Yi\} and Liaw, \{Jiunn Woei\} and Ma, \{Chen Chi M.\} and Wei, \{Kuo Chen\}",

note = "Funding Information: We thank the National Science Council of the Republic of China, National Department of Health of the Republic of China, Ministry of Economic Affairs , and Chang Gung Memorial Hospital , National Tsing Hua University for financial aid (NSC-101-2120-M-182A-002, NSC 100-2218-E-182-001-, NSC101-2321-B-182-015-, NSC101-2221-E-182-002-MY3, NHRI-EX102-10004NI, CMRPG3A0502, CMRPG3B0451, CMRPG3C0351, 102N2024E1, 102N2772E1). The authors also thank the Microscopy Core Laboratory of Chang Gung Memorial Hospital.",

year = "2013",

month = jul,

doi = "10.1016/j.biomaterials.2013.03.085",

language = "English",

volume = "34",

pages = "5651--5660",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier Limited",

number = "22",

}

TY - JOUR

T1 - Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy

AU - Yang, Hung Wei

AU - Liu, Hao Li

AU - Li, Meng Lin

AU - Hsi, I. Wen

AU - Fan, Chih Tai

AU - Huang, Chiung Yin

AU - Lu, Yu Jen

AU - Hua, Mu Yi

AU - Chou, Hsin Yi

AU - Liaw, Jiunn Woei

AU - Ma, Chen Chi M.

AU - Wei, Kuo Chen

N1 - Funding Information: We thank the National Science Council of the Republic of China, National Department of Health of the Republic of China, Ministry of Economic Affairs , and Chang Gung Memorial Hospital , National Tsing Hua University for financial aid (NSC-101-2120-M-182A-002, NSC 100-2218-E-182-001-, NSC101-2321-B-182-015-, NSC101-2221-E-182-002-MY3, NHRI-EX102-10004NI, CMRPG3A0502, CMRPG3B0451, CMRPG3C0351, 102N2024E1, 102N2772E1). The authors also thank the Microscopy Core Laboratory of Chang Gung Memorial Hospital.

PY - 2013/7

Y1 - 2013/7

N2 - Nanomedicine can provide a multi-functional platform for image-guided diagnosis and treatment of cancer. Although gold nanorods (GNRs) have been developed for photoacoustic (PA) imaging and near infra-red (NIR) photothermal applications, their efficiency has remained limited by low thermal stability. Here we present the synthesis, characterization, and functional evaluation of non-cytotoxic magnetic polymer-modified gold nanorods (MPGNRs), designed to act as dual magnetic resonance imaging (MRI) and PA imaging contrast agents. In addition, their high magnetization allowed MPGNRs to be actively localized and concentrated by targeting with an external magnet. Finally, MPGNRs significantly enhanced the NIR-laser-induced photothermal effect due to their increased thermal stability. MPGNRs thus provide a promising new theranostic platform for cancer diagnosis and treatment by combining dual MR/PA imaging with highly effective targeted photothermal therapy.

AB - Nanomedicine can provide a multi-functional platform for image-guided diagnosis and treatment of cancer. Although gold nanorods (GNRs) have been developed for photoacoustic (PA) imaging and near infra-red (NIR) photothermal applications, their efficiency has remained limited by low thermal stability. Here we present the synthesis, characterization, and functional evaluation of non-cytotoxic magnetic polymer-modified gold nanorods (MPGNRs), designed to act as dual magnetic resonance imaging (MRI) and PA imaging contrast agents. In addition, their high magnetization allowed MPGNRs to be actively localized and concentrated by targeting with an external magnet. Finally, MPGNRs significantly enhanced the NIR-laser-induced photothermal effect due to their increased thermal stability. MPGNRs thus provide a promising new theranostic platform for cancer diagnosis and treatment by combining dual MR/PA imaging with highly effective targeted photothermal therapy.

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DO - 10.1016/j.biomaterials.2013.03.085

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AN - SCOPUS:84877597874

SN - 0142-9612

VL - 34

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EP - 5660

JO - Biomaterials

JF - Biomaterials

IS - 22

ER -

Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy

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All Science Journal Classification (ASJC) codes

UN SDG

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